The influenza virus PA endonuclease, which cleaves capped cellular pre-mRNAs to prime viral mRNA synthesis, is a promising target for novel anti-influenza virus therapeutics. We evaluated a series of β-diketo acid (DKA) derivatives containing different scaffolds, and determined their structure-activity relationship in an enzymatic assay with the N-terminal part of PA (PA-Nter). We propose a pharmacophore model that defines strict structural requirements along with chemical features, to serve as the basis for design of novel PA inhibitors (PAIs) with DKA-based structures or bioisosteres thereof. Besides, we developed a molecular beacon-based PA-Nter assay which is amenable to high-throughput screening. This method also enables to compare the...
Influenza viruses cause seasonal epidemics as well as pandemic outbreaks, associated with huge econo...
Influenza is a highly contagious infectious disease that affects millions of people every year. In t...
Searching for new antiviral agents, we focused our interest on the influenza PA-Nter endonuclease. T...
Introduction: Due to rising resistance to the existing anti-influenza virus drugs, new antiviral age...
The influenza virus PA endonuclease, which cleaves capped cellular pre-mRNAs to prime viral mRNA syn...
The influenza virus PA endonuclease, which cleaves capped cellular pre-mRNAs to prime viral mRNA syn...
The influenza virus PA endonuclease, which cleaves capped cellular pre-mRNAs to prime viral mRNA syn...
Vaccination and antiviral therapy are the primary measures to combat human influenza viruses. Howeve...
Vaccination and antiviral agents are the primary measures against human influenza viruses. However, ...
The influenza virus RNA-dependent RNA polymerase complex (RdRp), a heterotrimeric protein complex re...
The influenza virus RNA-dependent RNA polymerase complex (RdRp), a heterotrimeric protein complex re...
The influenza virus PA endonuclease, which cleaves capped cellular pre-mRNAs to prime viral mRNA syn...
The influenza virus RNA-dependent RNA polymerase complex (RdRp), a heterotrimeric protein complex re...
The influenza virus PA endonuclease cleaves host pre-mRNAs to generate capped primers for viral mRNA...
Influenza is a highly contagious infectious disease that affects millions of people every year. In t...
Influenza viruses cause seasonal epidemics as well as pandemic outbreaks, associated with huge econo...
Influenza is a highly contagious infectious disease that affects millions of people every year. In t...
Searching for new antiviral agents, we focused our interest on the influenza PA-Nter endonuclease. T...
Introduction: Due to rising resistance to the existing anti-influenza virus drugs, new antiviral age...
The influenza virus PA endonuclease, which cleaves capped cellular pre-mRNAs to prime viral mRNA syn...
The influenza virus PA endonuclease, which cleaves capped cellular pre-mRNAs to prime viral mRNA syn...
The influenza virus PA endonuclease, which cleaves capped cellular pre-mRNAs to prime viral mRNA syn...
Vaccination and antiviral therapy are the primary measures to combat human influenza viruses. Howeve...
Vaccination and antiviral agents are the primary measures against human influenza viruses. However, ...
The influenza virus RNA-dependent RNA polymerase complex (RdRp), a heterotrimeric protein complex re...
The influenza virus RNA-dependent RNA polymerase complex (RdRp), a heterotrimeric protein complex re...
The influenza virus PA endonuclease, which cleaves capped cellular pre-mRNAs to prime viral mRNA syn...
The influenza virus RNA-dependent RNA polymerase complex (RdRp), a heterotrimeric protein complex re...
The influenza virus PA endonuclease cleaves host pre-mRNAs to generate capped primers for viral mRNA...
Influenza is a highly contagious infectious disease that affects millions of people every year. In t...
Influenza viruses cause seasonal epidemics as well as pandemic outbreaks, associated with huge econo...
Influenza is a highly contagious infectious disease that affects millions of people every year. In t...
Searching for new antiviral agents, we focused our interest on the influenza PA-Nter endonuclease. T...