Add to ORKGIntestinal epithelial cells (IECs) at the internal/external interface orchestrate the mucosal immune response. Paneth cells secrete antimicrobial peptides and inflammatory mediators, protect from pathogens and shape the commensal microbiota. Prompted by the genetic association of the locus harbouring the type I interferon (IFN) receptor (IFNAR1) with Crohn's disease, and a transcriptional signature for type I IFN signalling in Paneth cells, we studied the function of IFNAR1 in IECs.status: publishe
Type I Interferon (IFN) responses are considered the primary means by which viral infections are con...
Backgound & Aims: Several lines of investigation suggest that interferon (IFN) alpha can alter human...
Interferons (IFNs) are key host cytokines in the innate immune response to viral infection, and rece...
Objective Intestinal epithelial cells (IECs) at the internal/external interface orchestrate the muco...
Objective Intestinal epithelial cells (IECs) at the internal/external interface orchestrate the muco...
Interferon λ (IFN-λ) is critical for host viral defense at mucosal surfaces and stimulates immunomod...
Intestinal homeostasis is a delicate balance between suppression of immune responses against innocuo...
Background and Aims - Intestinal epithelial cells [IECs] secrete cytokines that recruit immune cells...
While interferons help kill virally infected cells, they can also promote systemic immune responses ...
The intestinal mucosa forms an active interface to the outside word, facilitating nutrient and water...
The intestinal mucosa forms an active interface to the outside word, facilitating nutrient and water...
The interferon (IFN)-stimulated gene factor 3 (ISGF3) transcription factor with its Stat1, Stat2, an...
Paneth cells and Lgr5+ intestinal stem cells (Lgr5+ ISCs) constitute the stem cell niche and maintai...
Type I Interferon (IFN) responses are considered the primary means by which viral infections are con...
Interferon-lambda (IFN-λ) protects intestinal epithelial cells (IECs) from enteric viruses by induci...
Type I Interferon (IFN) responses are considered the primary means by which viral infections are con...
Backgound & Aims: Several lines of investigation suggest that interferon (IFN) alpha can alter human...
Interferons (IFNs) are key host cytokines in the innate immune response to viral infection, and rece...
Objective Intestinal epithelial cells (IECs) at the internal/external interface orchestrate the muco...
Objective Intestinal epithelial cells (IECs) at the internal/external interface orchestrate the muco...
Interferon λ (IFN-λ) is critical for host viral defense at mucosal surfaces and stimulates immunomod...
Intestinal homeostasis is a delicate balance between suppression of immune responses against innocuo...
Background and Aims - Intestinal epithelial cells [IECs] secrete cytokines that recruit immune cells...
While interferons help kill virally infected cells, they can also promote systemic immune responses ...
The intestinal mucosa forms an active interface to the outside word, facilitating nutrient and water...
The intestinal mucosa forms an active interface to the outside word, facilitating nutrient and water...
The interferon (IFN)-stimulated gene factor 3 (ISGF3) transcription factor with its Stat1, Stat2, an...
Paneth cells and Lgr5+ intestinal stem cells (Lgr5+ ISCs) constitute the stem cell niche and maintai...
Type I Interferon (IFN) responses are considered the primary means by which viral infections are con...
Interferon-lambda (IFN-λ) protects intestinal epithelial cells (IECs) from enteric viruses by induci...
Type I Interferon (IFN) responses are considered the primary means by which viral infections are con...
Backgound & Aims: Several lines of investigation suggest that interferon (IFN) alpha can alter human...
Interferons (IFNs) are key host cytokines in the innate immune response to viral infection, and rece...