Add to ORKGA series of pro-nucleotide phosphoramidates and phosphorodiamidates of the antiviral lead compound 3'-deoxy-3'-fluorothymidine (FLT) have been designed and synthesized. In vitro antiretroviral and cytostatic studies revealed potent (sub-micromolar) inhibition of HIV-1 and HIV-2 replication, with retention of activity in thymidine kinase-negative cell models, as predicted by the ProTide concept.status: publishe
Among the many prodrug approaches aimed at delivering nucleoside monophosphates into cells, the phos...
2′,3′-Dideoxyguanosine (ddG) is a nucleoside analogue that has been found to exert a relatively mode...
2′,3′-Dideoxyguanosine (ddG) is a nucleoside analogue that has been found to exert a relatively mode...
A series of pro-nucleotide phosphoramidates and phosphorodiamidates of the antiviral lead compound 3...
A series of pro-nucleotide phosphoramidates and phosphorodiamidates of the antiviral lead compound 3...
A series of pro-nucleotide phosphoramidates and phosphorodiamidates of the antiviral lead compound 3...
A series of pro-nucleotide phosphoramidates and phosphorodiamidates of the antiviral lead compound 3...
A series of pro-nucleotide phosphoramidates and phosphorodiamidates of the antiviral lead compound 3...
The anti-HIV activity of nucleoside analogues is highly related to their substrate specificity for c...
This project describes the synthesis of some novel alkyl and aryl masked nucleotides of thymidine an...
To assess the structure-activity relationship for antiviral activity, a series of 3'-deoxy-3'-N-func...
L-α-2′-Deoxythreosyl nucleoside phosphonates and their phosphonodiamidate prodrugs with a hypoxanthi...
The synthesis and in vitro anti human immunodeficiency virus (HIV) and anti-hepatitis B virus (HBV) ...
We herein report the application of the phosphorodiamidate phosphate prodrug approach to a series of...
A series of base-modified pyrimidine 3'-azido-2',3'-dideoxynucleosides and 3'-substituted purine and...
Among the many prodrug approaches aimed at delivering nucleoside monophosphates into cells, the phos...
2′,3′-Dideoxyguanosine (ddG) is a nucleoside analogue that has been found to exert a relatively mode...
2′,3′-Dideoxyguanosine (ddG) is a nucleoside analogue that has been found to exert a relatively mode...
A series of pro-nucleotide phosphoramidates and phosphorodiamidates of the antiviral lead compound 3...
A series of pro-nucleotide phosphoramidates and phosphorodiamidates of the antiviral lead compound 3...
A series of pro-nucleotide phosphoramidates and phosphorodiamidates of the antiviral lead compound 3...
A series of pro-nucleotide phosphoramidates and phosphorodiamidates of the antiviral lead compound 3...
A series of pro-nucleotide phosphoramidates and phosphorodiamidates of the antiviral lead compound 3...
The anti-HIV activity of nucleoside analogues is highly related to their substrate specificity for c...
This project describes the synthesis of some novel alkyl and aryl masked nucleotides of thymidine an...
To assess the structure-activity relationship for antiviral activity, a series of 3'-deoxy-3'-N-func...
L-α-2′-Deoxythreosyl nucleoside phosphonates and their phosphonodiamidate prodrugs with a hypoxanthi...
The synthesis and in vitro anti human immunodeficiency virus (HIV) and anti-hepatitis B virus (HBV) ...
We herein report the application of the phosphorodiamidate phosphate prodrug approach to a series of...
A series of base-modified pyrimidine 3'-azido-2',3'-dideoxynucleosides and 3'-substituted purine and...
Among the many prodrug approaches aimed at delivering nucleoside monophosphates into cells, the phos...
2′,3′-Dideoxyguanosine (ddG) is a nucleoside analogue that has been found to exert a relatively mode...
2′,3′-Dideoxyguanosine (ddG) is a nucleoside analogue that has been found to exert a relatively mode...