Reduced tumorigenicity and pathogenicity of cervical carcinoma SiHa cells selected for resistance to cidofovir
- De Schutter, Tim
- Andrei, Graciela
- Topalis, Dimitrios
- Duraffour, Sophie
- Mitera, Tania
- van den Oord, Joost
- Matthys, Patrick
- Snoeck, Robert
Publication date
December 2013
DOI Publisher
BioMed Central ISSN
1476-4598 Journal
issn:1476-4598 Citation count (estimate)
4Abstract
Insights into the mechanisms associated with chemotherapy-resistance are important for implementation of therapeutic strategies and for unraveling the mode of action of chemotherapeutics. Although cidofovir (CDV) has proven efficacious in the treatment of human papillomavirus (HPV)-induced proliferation, no studies concerning the development of resistance to CDV in HPV-positive tumor cells have been performed yet.status: publishe
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