The use of DNA and viral vector-based vaccines for the induction of cellular immune responses is increasingly gaining interest. However, concerns have been raised regarding the safety of these immunization strategies. Due to the lack of their genome integration, mRNA-based vaccines have emerged as a promising alternative. In this study, we evaluated the potency of antigen-encoding mRNA complexed with the cationic lipid 1,2-dioleoyl-3trimethylammonium-propane/1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOTAP/DOPE ) as a novel vaccination approach. We demonstrate that subcutaneous immunization of mice with mRNA encoding the HIV-1 antigen Gag complexed with DOTAP/DOPE elicits antigen-specific, functional T cell responses resulting in specif...
RNA-based vaccines have recently emerged as a promising alternative to the use of DNA-based and vira...
International audienceIntravenous (i‧v.) delivery of vaccines is emerging as an appealing approach t...
Immunogenicity of HIV-1 mRNA vaccine regimens was analyzed in a non-human primate animal model. Rhes...
The use of DNA and viral vector-based vaccines for the induction of cellular immune responses is inc...
Cancer vaccines based on mRNA are extensively studied. The fragile nature of mRNA has instigated res...
Cancer vaccines based on mRNA are extensively studied. The fragile nature of mRNA has instigated res...
Given their high potential to evoke cytolytic T cell responses, tumor antigen-encoding messenger RNA...
Given their high potential to evoke cytolytic T cell responses, tumor antigen-encoding messenger RNA...
Aim: Cationic lipids (Lipofectamine [Invitrogen, Merelbeke, Belgium] and 1,2-dioleoyl-3-trimethylamm...
When the cationic lipid DOTAP (1,2-dioleyltrimethylammoniumpropane) is used to encapsulate an antige...
Aim: Cationic lipids (Lipofectamine (TM) [Invitrogen, Merelbeke, Belgium] and 1,2-dioleoyl-3-trimeth...
Lipid nanoparticles (LNPs) are at the forefront of scientific thought due to the SARS-CoV-2 pandemic...
In the last three decades, an improved understanding of the mRNA pharmacology, together with novel i...
Adjuvants are essential components of subunit vaccines added to enhance immune responses to antigens...
It is clear that new approaches are needed to promote broadly protective immunity to viral pathogens...
RNA-based vaccines have recently emerged as a promising alternative to the use of DNA-based and vira...
International audienceIntravenous (i‧v.) delivery of vaccines is emerging as an appealing approach t...
Immunogenicity of HIV-1 mRNA vaccine regimens was analyzed in a non-human primate animal model. Rhes...
The use of DNA and viral vector-based vaccines for the induction of cellular immune responses is inc...
Cancer vaccines based on mRNA are extensively studied. The fragile nature of mRNA has instigated res...
Cancer vaccines based on mRNA are extensively studied. The fragile nature of mRNA has instigated res...
Given their high potential to evoke cytolytic T cell responses, tumor antigen-encoding messenger RNA...
Given their high potential to evoke cytolytic T cell responses, tumor antigen-encoding messenger RNA...
Aim: Cationic lipids (Lipofectamine [Invitrogen, Merelbeke, Belgium] and 1,2-dioleoyl-3-trimethylamm...
When the cationic lipid DOTAP (1,2-dioleyltrimethylammoniumpropane) is used to encapsulate an antige...
Aim: Cationic lipids (Lipofectamine (TM) [Invitrogen, Merelbeke, Belgium] and 1,2-dioleoyl-3-trimeth...
Lipid nanoparticles (LNPs) are at the forefront of scientific thought due to the SARS-CoV-2 pandemic...
In the last three decades, an improved understanding of the mRNA pharmacology, together with novel i...
Adjuvants are essential components of subunit vaccines added to enhance immune responses to antigens...
It is clear that new approaches are needed to promote broadly protective immunity to viral pathogens...
RNA-based vaccines have recently emerged as a promising alternative to the use of DNA-based and vira...
International audienceIntravenous (i‧v.) delivery of vaccines is emerging as an appealing approach t...
Immunogenicity of HIV-1 mRNA vaccine regimens was analyzed in a non-human primate animal model. Rhes...