Autosomal dominant polycystic kidney disease (ADPKD) is caused by loss-of-function mutations in either PKD1 or PKD2 genes, which encode polycystin-1 (TRPP1) and polycystin-2 (TRPP2), respectively. Increased activity of the mammalian target of rapamycin (mTOR) pathway has been shown in PKD1 mutants but is less documented for PKD2 mutants. Clinical trials using mTOR inhibitors were disappointing, while the AMP-activated kinase (AMPK) activator, metformin is not yet tested in patients. Here, we studied the mTOR activity and its upstream pathways in several human and mouse renal cell models with either siRNA or stable knockdown and with overexpression of TRPP2. Our data reveal for the first time differences between TRPP1 and TRPP2 deficiency. I...
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the development of kidney c...
The mammalian target of rapamycin (mTOR) signaling pathway is aberrantly activated in polycystic kid...
The mammalian target of rapamycin (mTOR) signaling pathway is aberrantly activated in polycystic kid...
Autosomal dominant polycystic kidney disease (ADPKD) is caused by loss-of-function mutations in eith...
Contains fulltext : 136542.pdf (publisher's version ) (Closed access)Autosomal dom...
AbstractAutosomal dominant polycystic kidney disease (ADPKD) is the most common life-threatening her...
Autosomal dominant polycystic kidney disease (ADPKD) is the most commonmonogenic disorder leading ul...
Autosomal dominant polycystic kidney disease (ADPKD) is the most common life-threatening hereditary ...
Autosomal-dominant polycystic kidney disease (ADPKD) is the most common heritable kidney disorder wi...
The immunosuppressive drug rapamycin has helped to identify a large signaling network around the tar...
The mammalian target of rapamycin (mTOR) signaling pathway is aberrantly activated in polycystic kid...
AbstractAutosomal dominant polycystic kidney disease (ADPKD) is the most common life-threatening her...
Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited disorder that is caused b...
Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited disorder that is caused b...
Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited disorder that is caused b...
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the development of kidney c...
The mammalian target of rapamycin (mTOR) signaling pathway is aberrantly activated in polycystic kid...
The mammalian target of rapamycin (mTOR) signaling pathway is aberrantly activated in polycystic kid...
Autosomal dominant polycystic kidney disease (ADPKD) is caused by loss-of-function mutations in eith...
Contains fulltext : 136542.pdf (publisher's version ) (Closed access)Autosomal dom...
AbstractAutosomal dominant polycystic kidney disease (ADPKD) is the most common life-threatening her...
Autosomal dominant polycystic kidney disease (ADPKD) is the most commonmonogenic disorder leading ul...
Autosomal dominant polycystic kidney disease (ADPKD) is the most common life-threatening hereditary ...
Autosomal-dominant polycystic kidney disease (ADPKD) is the most common heritable kidney disorder wi...
The immunosuppressive drug rapamycin has helped to identify a large signaling network around the tar...
The mammalian target of rapamycin (mTOR) signaling pathway is aberrantly activated in polycystic kid...
AbstractAutosomal dominant polycystic kidney disease (ADPKD) is the most common life-threatening her...
Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited disorder that is caused b...
Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited disorder that is caused b...
Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited disorder that is caused b...
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the development of kidney c...
The mammalian target of rapamycin (mTOR) signaling pathway is aberrantly activated in polycystic kid...
The mammalian target of rapamycin (mTOR) signaling pathway is aberrantly activated in polycystic kid...