This paper studies the influence of build orientation and mean stress on the very-high-cycle fatigue (VHCF) behavior of AlSi10Mg fabricated by selective laser melting (SLM). Horizontally built specimens demonstrate better mechanical performance than vertically built specimens. Four crack initiation modes are identified for the specimens in high-cycle fatigue (HCF) and VHCF regimes, namely initiation by lack-of-fusion, initiation by internal pore, initiation with no obvious defect and initiation by tearing. Moreover, it turns out that the mean stress accelerates crack initiation, and hence reduces fatigue life. A model is proposed to describe the effect of crack initiation location on fatigue strength