Arsenic (+3 oxidation state) methyltransferase (AS3MT) is the key enzyme in the pathway for methylation of arsenicals. A common polymorphism in the AS3MT gene that replaces a threonyl residue in position 287 with a methionyl residue (AS3MT/M287T) occurs at a frequency of about 10% among populations worldwide. Here, we compared catalytic properties of recombinant human wild-type (wt) AS3MT and AS3MT/M287T in reaction mixtures containing S-adenosylmethionine, arsenite (iAsIII) or methylarsonous acid (MAsIII) as substrates and endogenous or synthetic reductants, including glutathione (GSH), a thioredoxin reductase (TR)/thioredoxin (Trx)/NADPH reducing system, or tris (2-carboxyethyl) phosphine hydrochloride (TCEP). With either TR/Trx/NADPH or ...
Exposure to naturally occurring inorganic arsenic (iAs), primarily from contaminated drinking water,...
Arsenic methyltransferase (As3mt) catalyzes the conversion of inorganic arsenic (iAs) to its methyla...
The formation of methylarsonous acid (MAsIII) and dimethylarsinous acid (DMAsIII) in the course of i...
Arsenic (+3 oxidation state) methyltransferase (AS3MT) is the key enzyme in the pathway for methylat...
A synthetic gene encoding human As(III) S-adenosylmethionine (SAM) methyltransferase (hAS3MT) was ex...
A synthetic gene encoding human As(III) S-adenosylmethionine (SAM) methyltransferase (hAS3MT) was ex...
S-Adenosyl-l-methionine (AdoMet):arsenic(III) methyltransferase, purified from liver cytosol of adul...
S-Adenosyl-L-methionine (AdoMet):arsenic(III) methyltransferase, purified from liver cytosol of adul...
Several methyltransferases have been shown to catalyze the oxidative methylation of inorganic arseni...
ABSTRACT: A synthetic gene encoding human As(III) S-adenosylmethionine (SAM) methyltransferase (hAS3...
The arsenic (+3 oxidation state) methyltransferase (As3mt) gene encodes a 43 kDa protein that cataly...
Arsenic is the most pervasive environmental toxic substance. As a consequence of its ubiquity, nearl...
Biomethylation is the major pathway for the metabolism of inorganic arsenic (iAs) in many mammalian ...
Recent research of the metabolism and biological effects of arsenic has profoundly changed our under...
Metabolic conversion of inorganic arsenic into methylated products is a multistep process that yield...
Exposure to naturally occurring inorganic arsenic (iAs), primarily from contaminated drinking water,...
Arsenic methyltransferase (As3mt) catalyzes the conversion of inorganic arsenic (iAs) to its methyla...
The formation of methylarsonous acid (MAsIII) and dimethylarsinous acid (DMAsIII) in the course of i...
Arsenic (+3 oxidation state) methyltransferase (AS3MT) is the key enzyme in the pathway for methylat...
A synthetic gene encoding human As(III) S-adenosylmethionine (SAM) methyltransferase (hAS3MT) was ex...
A synthetic gene encoding human As(III) S-adenosylmethionine (SAM) methyltransferase (hAS3MT) was ex...
S-Adenosyl-l-methionine (AdoMet):arsenic(III) methyltransferase, purified from liver cytosol of adul...
S-Adenosyl-L-methionine (AdoMet):arsenic(III) methyltransferase, purified from liver cytosol of adul...
Several methyltransferases have been shown to catalyze the oxidative methylation of inorganic arseni...
ABSTRACT: A synthetic gene encoding human As(III) S-adenosylmethionine (SAM) methyltransferase (hAS3...
The arsenic (+3 oxidation state) methyltransferase (As3mt) gene encodes a 43 kDa protein that cataly...
Arsenic is the most pervasive environmental toxic substance. As a consequence of its ubiquity, nearl...
Biomethylation is the major pathway for the metabolism of inorganic arsenic (iAs) in many mammalian ...
Recent research of the metabolism and biological effects of arsenic has profoundly changed our under...
Metabolic conversion of inorganic arsenic into methylated products is a multistep process that yield...
Exposure to naturally occurring inorganic arsenic (iAs), primarily from contaminated drinking water,...
Arsenic methyltransferase (As3mt) catalyzes the conversion of inorganic arsenic (iAs) to its methyla...
The formation of methylarsonous acid (MAsIII) and dimethylarsinous acid (DMAsIII) in the course of i...