Livers and hearts from mice deficient in glycerol-3-phosphate acyltransferase 1 (GPAT1; Gpat1−/−) have a decreased content of glycerolipid intermediates and triacylglycerol, an altered composition of liver phospholipids, and elevated markers of oxidative stress. Compared with control C57BL/6 mice, infection of Gpat1−/− mice with coxsackievirus B3 (CVB3) resulted in higher mortality, an ∼50% increase in heart pathology, a significant increase in liver viral titers, and a 100-fold increase in heart viral titers. Moreover, heart mRNA levels for proinflammatory cytokines tumor necrosis factor-α, interleukin (IL)-6, and IL-1B were increased in the Gpat1−/− mice. Loss of Gpat1 also resulted in dysregulation of specific immune cells. Splenic dendr...
The metabolic derangements present in type 2 diabetes are associated with the accumulation of triacy...
Glycerol-3-phosphate acyltransferase (GPAT) catalyzes the initial and rate-limiting step in glycerol...
Coxsackievirus A2 (CVA2) has emerged as an active pathogen that has been implicated in hand, foot, a...
Livers and hearts from mice deficient in glycerol-3-phosphate acyltransferase 1 (GPAT1; Gpat1−/−) ha...
Glycerol-3-phosphate acyltransferase-1 (GPAT1), which is located on the outer mitochondrial membrane...
textThe aged T cell is characterized by decreased responsiveness to stimulation. Aging is associated...
The risk of hepatocellular carcinoma increases with the persistence of non-alcoholic fatty liver dis...
The absence of mouse mitochondrial glycerol-3-phosphate acyltransferase-1 (Gpat1-/-) increases the a...
Elucidation of the metabolic pathways of triacylglycerol (TAG) synthesis is critical to the understa...
GPAT1, one of four known glycerol-3-phosphate acyltransferase isoforms, is located on the mitochondr...
Coxsackievirus B3 (CVB3) is a leading cause of viral myocarditis, but no effective treatment strateg...
Synthesis of triacylglycerol (TAG) is critical for the formation of lipoproteins and lipid droplets ...
Triacylglycerol (TAG) is a fat that serves as a vital energy source in eukaryotes. TAG is synthesize...
Glycerol-3-phosphate acyltransferase (GPAT) catalyzes the initial and rate-limiting step of glycerol...
textAging is associated with immune dysfunction, characterized by reduced Tlymphocyte proliferation ...
The metabolic derangements present in type 2 diabetes are associated with the accumulation of triacy...
Glycerol-3-phosphate acyltransferase (GPAT) catalyzes the initial and rate-limiting step in glycerol...
Coxsackievirus A2 (CVA2) has emerged as an active pathogen that has been implicated in hand, foot, a...
Livers and hearts from mice deficient in glycerol-3-phosphate acyltransferase 1 (GPAT1; Gpat1−/−) ha...
Glycerol-3-phosphate acyltransferase-1 (GPAT1), which is located on the outer mitochondrial membrane...
textThe aged T cell is characterized by decreased responsiveness to stimulation. Aging is associated...
The risk of hepatocellular carcinoma increases with the persistence of non-alcoholic fatty liver dis...
The absence of mouse mitochondrial glycerol-3-phosphate acyltransferase-1 (Gpat1-/-) increases the a...
Elucidation of the metabolic pathways of triacylglycerol (TAG) synthesis is critical to the understa...
GPAT1, one of four known glycerol-3-phosphate acyltransferase isoforms, is located on the mitochondr...
Coxsackievirus B3 (CVB3) is a leading cause of viral myocarditis, but no effective treatment strateg...
Synthesis of triacylglycerol (TAG) is critical for the formation of lipoproteins and lipid droplets ...
Triacylglycerol (TAG) is a fat that serves as a vital energy source in eukaryotes. TAG is synthesize...
Glycerol-3-phosphate acyltransferase (GPAT) catalyzes the initial and rate-limiting step of glycerol...
textAging is associated with immune dysfunction, characterized by reduced Tlymphocyte proliferation ...
The metabolic derangements present in type 2 diabetes are associated with the accumulation of triacy...
Glycerol-3-phosphate acyltransferase (GPAT) catalyzes the initial and rate-limiting step in glycerol...
Coxsackievirus A2 (CVA2) has emerged as an active pathogen that has been implicated in hand, foot, a...