HIV-1 Expression Within Resting CD4+ T Cells After Multiple Doses of Vorinostat
- Archin, N. M.
- Bateson, R.
- Tripathy, M. K.
- Crooks, A. M.
- Yang, K.-H.
- Dahl, N. P.
- Kearney, M. F.
- Anderson, E. M.
- Coffin, J. M.
- Strain, M. C.
- Richman, D. D.
- Robertson, K. R.
- Kashuba, A. D.
- Bosch, R. J.
- Hazuda, D. J.
- Kuruc, J. D.
- Eron, J. J.
- Margolis, D. M.
Publication date
January 2014
DOIAbstract
Background. A single dose of the histone deacetylase inhibitor vorinostat (VOR) up-regulates HIV RNA expression within resting CD4+ T cells of treated, aviremic human immunodeficiency virus (HIV)–positive participants. The ability of multiple exposures to VOR to repeatedly disrupt latency has not been directly measured, to our knowledge
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