Proteinuria, CrCl, and Immune Activation in Antiretroviral-Naïve HIV-Infected Subjects
- Gupta, Samir K.
- Komarow, Lauren
- Gulick, Roy M.
- Pollard, Richard B.
- Robbins, Gregory K.
- Franceschini, Nora
- Szczech, Lynda A.
- Koletar, Susan L.
- Kalayjian, Robert C.
Publication date
January 2009
DOIAbstract
Because both renal disease and immune activation predict progression to AIDS, we evaluated the relationships between dipstick proteinuria ≥1+ [7% of 1012 subjects], CrCl <90mL/min [18% of 1071 subjects], and percentages of peripheral activated CD8 cells (CD8+CD38+HLA-DR+) in antiretroviral-naïve, HIV-infected subjects enrolled into AIDS Clinical Trials Group studies 384 and A5095. Proteinuria, but not CrCl, was associated with higher percentages of CD8+CD38+HLA-DR+ cells [55% vs. 50%; P=0.01], with even more pronounced differences in men and among Blacks and Hispanics. Proteinuria may be a surrogate measure of greater immune activation in HIV-infected patients initiating antiretroviral therapy
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