Modulation of the extracellular signal-regulated kinases (ERK-1/2), a signaling pathway directly associated with cell proliferation, survival, and homeostasis, has been implicated in several pathologies, including alcoholic liver disease. However, the underlying mechanism of ethanol-induced ERK-1/2 modulation remains unknown. This investigation explored the effects of ethanol-associated oxidative stress on constitutive hepatic ERK-1/2 activity and assessed the contribution of the lipid peroxidation product 4-hydroxynonenal (4-HNE) to the observations made in vivo. Constitutive ERK-1/2 phosphorylation was suppressed in hepatocytes isolated from rats chronically consuming ethanol for 45 days. This observation was associated with an increase i...
Binge alcohol drinking is a particularly risky pattern of alcohol consumption that often precedes al...
BackgroundAlcohol insult triggers complex events in the liver, promoting fibrogenic/inflammatory sig...
Chronic alcohol consumption is a well-known risk factor for liver disease. Progression of alcohol-in...
Modulation of the extracellular signal-regulated kinases (ERK-1/2), a signaling pathway directly ass...
AbstractChronic ethanol-mediated oxidative stress and lipid peroxidation increases the levels of var...
Alcoholic liver disease causes oxidative stress and induces apoptosis during alcohol metabolism. Eth...
Introduction: The pathogenesis of acute and chronic alcohol consumption is complex with diverse cons...
Long-term alcohol exposure sensitizes hepatocytes to tumor necrosis factor-α (TNF) cytotoxicity. 4-H...
Alcohol abuse is the third leading cause of preventable death in the United States. Excessive intake...
Drug induced hepatotoxicity is the most common reason cited for withdrawal of already approved drugs...
Extracellular signal-regulated protein kinase (ERK1/2) is a member of the mitogen-activated protein ...
Alcohol-induced liver disease increasingly contributes to human mortality worldwide. Alcohol-induced...
AbstractAcute ethanol loading causes oxidative stress to activate cell-death signaling via c-Jun NH2...
2004; 10.1152/ajpgi.00056.2004.—Alcohol has long been thought to cause fatty liver by way of altered...
Alcohol insult triggers complex events in the liver, promoting fibrogenic/inflammatory signals and i...
Binge alcohol drinking is a particularly risky pattern of alcohol consumption that often precedes al...
BackgroundAlcohol insult triggers complex events in the liver, promoting fibrogenic/inflammatory sig...
Chronic alcohol consumption is a well-known risk factor for liver disease. Progression of alcohol-in...
Modulation of the extracellular signal-regulated kinases (ERK-1/2), a signaling pathway directly ass...
AbstractChronic ethanol-mediated oxidative stress and lipid peroxidation increases the levels of var...
Alcoholic liver disease causes oxidative stress and induces apoptosis during alcohol metabolism. Eth...
Introduction: The pathogenesis of acute and chronic alcohol consumption is complex with diverse cons...
Long-term alcohol exposure sensitizes hepatocytes to tumor necrosis factor-α (TNF) cytotoxicity. 4-H...
Alcohol abuse is the third leading cause of preventable death in the United States. Excessive intake...
Drug induced hepatotoxicity is the most common reason cited for withdrawal of already approved drugs...
Extracellular signal-regulated protein kinase (ERK1/2) is a member of the mitogen-activated protein ...
Alcohol-induced liver disease increasingly contributes to human mortality worldwide. Alcohol-induced...
AbstractAcute ethanol loading causes oxidative stress to activate cell-death signaling via c-Jun NH2...
2004; 10.1152/ajpgi.00056.2004.—Alcohol has long been thought to cause fatty liver by way of altered...
Alcohol insult triggers complex events in the liver, promoting fibrogenic/inflammatory signals and i...
Binge alcohol drinking is a particularly risky pattern of alcohol consumption that often precedes al...
BackgroundAlcohol insult triggers complex events in the liver, promoting fibrogenic/inflammatory sig...
Chronic alcohol consumption is a well-known risk factor for liver disease. Progression of alcohol-in...