Defining the Ischemic Penumbra Using Magnetic Resonance Oxygen Metabolic Index
- An, H.
- Ford, A. L.
- Chen, Y.
- Zhu, H.
- Ponisio, R.
- Kumar, G.
- Shanechi, A. M.
- Khoury, N.
- Vo, K. D.
- Williams, J.
- Derdeyn, C. P.
- Diringer, M. N.
- Panagos, P.
- Powers, W. J.
- Lee, J.-M.
- Lin, W.
Publication date
January 2015
DOIAbstract
Penumbral biomarkers promise to individualize treatment windows in acute ischemic stroke. We used a novel MRI approach which measures oxygen metabolic index (OMI), a parameter closely related to PET-derived cerebral metabolic rate of oxygen utilization, to derive a pair of ischemic thresholds: (1) an irreversible-injury threshold which differentiates ischemic core from penumbra and (2) a reversible-injury threshold which differentiates penumbra from tissue not-at-risk for infarction
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