Effects of the neuroactive steroid allopregnanolone on intracranial self-stimulation in C57BL/6J Mice
- Fish, Eric W.
- Whitman, Buddy J.
- DiBerto, Jeff F.
- Robinson, J. Elliott
- Morrow, A. Leslie
- Malanga, C. J.
Publication date
January 2014
DOIAbstract
The neuroactive steroid (3α,5α)-3-hydroxy-pregnan-20-one (3α,5α-THP, allopregnanolone) has effects on reward-related behaviors in mice and rats that suggest that it may activate brain reward circuits. Intracranial self-stimulation (ICSS) is an operant behavioral technique that detects changes in the sensitivity of brain reward circuitry following drug administration
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