Cytochrome P450 2J2 is protective against global cerebral ischemia in transgenic mice

Ophiopogonin D Reduces Myocardial Ischemia-Reperfusion Injury via Upregulating CYP2J3/EETs in Rats

Xiaoyan Huang
Yuguang Wang
Yi Wang
Liang Yang
Jia Wang
Yue Gao

September 2018

Background/Aims: Epoxyeicosatrienoic acids (EETs) are cytochrome P450 epoxygenase (CYP) metabolites ...

Examining the potential of PGE₂ receptor EP₄ as a neuroprotective target following ischaemic injury

Gibson, Claire
Grubb, Blair
Akram, Asha

January 2013

Ischaemic stroke instigates a series of pathological mechanisms which contribute to injury. Despite ...

Role of Endothelial Soluble Epoxide Hydrolase in Cerebrovascular Function and Ischemic Injury

Zhang, Wenri
Davis, Catherine M.
Edin, Matthew L.
Lee, Craig R.
Zeldin, Darryl C.
Alkayed, Nabil J.

January 2013

Soluble Epoxide Hydrolase (sEH) is a key enzyme in the metabolism and termination of action of epoxy...

Cytochrome P450 2J2 is protective against global cerebral ischemia in transgenic mice

Li, Rui
Xu, Xizhen
Chen, Chen
Yu, Xuefeng
Edin, Matthew L.
Degraff, Laura Miller
Lee, Craig R.
Zeldin, Darryl C.
Wang, Dao Wen

January 2012

Cytochrome P450 epoxygenase metabolites of arachidonic acid (EETs) have multiple cardiovascular effe...

Sex- and isoform-specific mechanism of neuroprotection by transgenic expression of P450 epoxygenase in vascular endothelium

Jia, Jia
Davis, Catherine M.
Zhang, Wenri
Edin, Matthew L.
Jouihan, Sari
Jia, Taiping
Bradbury, J. Alyce
Graves, Joan P.
DeGraff, Laura M.
Lee, Craig R.
Ronnekleiv, Oline
Wang, Ruikang
Xu, Yun
Zeldin, Darryl C.
Alkayed, Nabil J.

January 2016

Cytochrome P450 epoxygenases (CYP) metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs), ...

Role of Epoxyeicosatrienoic Acids in Protecting Against Ischemic Cardiomyopathy

Aliwarga, Theresa

January 2018

Thesis (Ph.D.)--University of Washington, 2018Epoxyeicosatrienoic acids (EETs) are metabolites of ar...

14,15-epoxyeicosatrienoic acid promotes production of brain derived neurotrophic factor from astrocytes and exerts neuroprotective effects during ischaemic injury

Yuan, L.
Liu, J.
Dong, R.
Zhu, J.
Tao, C.
Zheng, R.
Zhu, S.

January 2016

Aims: 14,15-Epoxyeicosatrienoic acid (14,15-EET) is abundantly expressed in brain and exerts protect...

EVALUATION OF EFFECTS OF CYP450 DERIVED EICOSANOIDS IN CEREBRAL ISCHEMIA

SHAIK, JAFAR SADIK

December 2013

Stroke and cardiac arrest (CA) both are characterized by severe fall in the cerebral blood flow (CBF...

CYP2J2 and EETs Protect against Oxidative Stress and Apoptosis in Vivo and in Vitro Following Lung Ischemia/Reperfusion

Wenshu Chen
Guanying Zheng
Shijiang Yang
Wei Ping
Xiangning Fu
Ni Zhang
Dao Wen Wang
Jianing Wang

May 2014

Background: Cytochrome P450 epoxygenase 2J2 (CYP2J2) metabolizes arachidonic acids to epoxyeicosatri...

Cytochrome P450 epoxygenases, soluble epoxide hydrolase, and the regulation of cardiovascular inflammation

Deng, Yangmei
Theken, Katherine N.
Lee, Craig R.

January 2010

The cytochrome P450 (CYP) epoxygenase enzymes CYP2J and CYP2C catalyze the epoxidation of arachidoni...

Mechanism of protection by soluble epoxide hydrolase inhibition in type 2 diabetic stroke. PLoS One 9:e97529

Kristen L. Zuloaga
Stephanie M. Krasnow
Xinxia Zhu
Wenri Zhang
Sari A. Jouihan
Robert E. Shangraw
Nabil J. Alkayed
Daniel L. Marks

January 2014

Inhibition of soluble epoxide hydrolase (sEH) is a potential target of therapy for ischemic injury. ...

14,15-EET Reduced Brain Injury from Cerebral Ischemia and Reperfusion via Suppressing Neuronal Parthanatos

Haipeng Zhao
Jing Tang
Hongyang Chen
Wei Gu
Huixia Geng
Lai Wang
Yanming Wang

September 2021

To investigate the effect of 14,15-EET on the parthanatos in neurons induced by cerebral ischemia an...

Vascular endothelial overexpression of human CYP2J2 (Tie2-CYP2J2 Tr) modulates cardiac oxylipin profiles and enhances coronary reactive hyperemia in mice.

Ahmad Hanif
Matthew L Edin
Darryl C Zeldin
Christophe Morisseau
John R Falck
Mohammed A Nayeem

January 2017

Arachidonic acid is metabolized to epoxyeicosatrienoic acids (EETs) by cytochrome (CYP) P450 epoxyge...

Vascular endothelial overexpression of human CYP2J2 (Tie2-CYP2J2 Tr) modulates cardiac oxylipin profiles and enhances coronary reactive hyperemia in mice

Hanif, Ahmad
Edin, Matthew L
Zeldin, Darryl C
Morisseau, Christophe
Falck, John R
Nayeem, Mohammed A

January 2017

Arachidonic acid is metabolized to epoxyeicosatrienoic acids (EETs) by cytochrome (CYP) P450 epoxyge...

TRANSLATIONAL APPROACHES TO UNDERSTANDING THE ROLE OF CYTOCHROME P450-DERIVED EPOXYEICOSATRIENOIC ACIDS IN CORONARY ARTERY DISEASE

Oni-Orisan, Akinyemi

January 2015

Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality in the United Stat...

Ophiopogonin D Reduces Myocardial Ischemia-Reperfusion Injury via Upregulating CYP2J3/EETs in Rats

Xiaoyan Huang
Yuguang Wang
Yi Wang
Liang Yang
Jia Wang
Yue Gao

September 2018

Background/Aims: Epoxyeicosatrienoic acids (EETs) are cytochrome P450 epoxygenase (CYP) metabolites ...

Examining the potential of PGE₂ receptor EP₄ as a neuroprotective target following ischaemic injury

Gibson, Claire
Grubb, Blair
Akram, Asha

January 2013

Ischaemic stroke instigates a series of pathological mechanisms which contribute to injury. Despite ...

Role of Endothelial Soluble Epoxide Hydrolase in Cerebrovascular Function and Ischemic Injury

Zhang, Wenri
Davis, Catherine M.
Edin, Matthew L.
Lee, Craig R.
Zeldin, Darryl C.
Alkayed, Nabil J.

January 2013

Soluble Epoxide Hydrolase (sEH) is a key enzyme in the metabolism and termination of action of epoxy...

Cytochrome P450 2J2 is protective against global cerebral ischemia in transgenic mice

Li, Rui
Xu, Xizhen
Chen, Chen
Yu, Xuefeng
Edin, Matthew L.
Degraff, Laura Miller
Lee, Craig R.
Zeldin, Darryl C.
Wang, Dao Wen

January 2012

Cytochrome P450 epoxygenase metabolites of arachidonic acid (EETs) have multiple cardiovascular effe...

Sex- and isoform-specific mechanism of neuroprotection by transgenic expression of P450 epoxygenase in vascular endothelium

Jia, Jia
Davis, Catherine M.
Zhang, Wenri
Edin, Matthew L.
Jouihan, Sari
Jia, Taiping
Bradbury, J. Alyce
Graves, Joan P.
DeGraff, Laura M.
Lee, Craig R.
Ronnekleiv, Oline
Wang, Ruikang
Xu, Yun
Zeldin, Darryl C.
Alkayed, Nabil J.

January 2016

Cytochrome P450 epoxygenases (CYP) metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs), ...

Role of Epoxyeicosatrienoic Acids in Protecting Against Ischemic Cardiomyopathy

Aliwarga, Theresa

January 2018

Thesis (Ph.D.)--University of Washington, 2018Epoxyeicosatrienoic acids (EETs) are metabolites of ar...

14,15-epoxyeicosatrienoic acid promotes production of brain derived neurotrophic factor from astrocytes and exerts neuroprotective effects during ischaemic injury

Yuan, L.
Liu, J.
Dong, R.
Zhu, J.
Tao, C.
Zheng, R.
Zhu, S.

January 2016

Aims: 14,15-Epoxyeicosatrienoic acid (14,15-EET) is abundantly expressed in brain and exerts protect...

EVALUATION OF EFFECTS OF CYP450 DERIVED EICOSANOIDS IN CEREBRAL ISCHEMIA

SHAIK, JAFAR SADIK

December 2013

Stroke and cardiac arrest (CA) both are characterized by severe fall in the cerebral blood flow (CBF...

CYP2J2 and EETs Protect against Oxidative Stress and Apoptosis in Vivo and in Vitro Following Lung Ischemia/Reperfusion

Wenshu Chen
Guanying Zheng
Shijiang Yang
Wei Ping
Xiangning Fu
Ni Zhang
Dao Wen Wang
Jianing Wang

May 2014

Background: Cytochrome P450 epoxygenase 2J2 (CYP2J2) metabolizes arachidonic acids to epoxyeicosatri...

Cytochrome P450 epoxygenases, soluble epoxide hydrolase, and the regulation of cardiovascular inflammation

Deng, Yangmei
Theken, Katherine N.
Lee, Craig R.

January 2010

The cytochrome P450 (CYP) epoxygenase enzymes CYP2J and CYP2C catalyze the epoxidation of arachidoni...

Mechanism of protection by soluble epoxide hydrolase inhibition in type 2 diabetic stroke. PLoS One 9:e97529

Kristen L. Zuloaga
Stephanie M. Krasnow
Xinxia Zhu
Wenri Zhang
Sari A. Jouihan
Robert E. Shangraw
Nabil J. Alkayed
Daniel L. Marks

January 2014

Inhibition of soluble epoxide hydrolase (sEH) is a potential target of therapy for ischemic injury. ...

14,15-EET Reduced Brain Injury from Cerebral Ischemia and Reperfusion via Suppressing Neuronal Parthanatos

Haipeng Zhao
Jing Tang
Hongyang Chen
Wei Gu
Huixia Geng
Lai Wang
Yanming Wang

September 2021

To investigate the effect of 14,15-EET on the parthanatos in neurons induced by cerebral ischemia an...

Vascular endothelial overexpression of human CYP2J2 (Tie2-CYP2J2 Tr) modulates cardiac oxylipin profiles and enhances coronary reactive hyperemia in mice.

Ahmad Hanif
Matthew L Edin
Darryl C Zeldin
Christophe Morisseau
John R Falck
Mohammed A Nayeem

January 2017

Arachidonic acid is metabolized to epoxyeicosatrienoic acids (EETs) by cytochrome (CYP) P450 epoxyge...

Vascular endothelial overexpression of human CYP2J2 (Tie2-CYP2J2 Tr) modulates cardiac oxylipin profiles and enhances coronary reactive hyperemia in mice

Hanif, Ahmad
Edin, Matthew L
Zeldin, Darryl C
Morisseau, Christophe
Falck, John R
Nayeem, Mohammed A

January 2017

Arachidonic acid is metabolized to epoxyeicosatrienoic acids (EETs) by cytochrome (CYP) P450 epoxyge...

TRANSLATIONAL APPROACHES TO UNDERSTANDING THE ROLE OF CYTOCHROME P450-DERIVED EPOXYEICOSATRIENOIC ACIDS IN CORONARY ARTERY DISEASE

Oni-Orisan, Akinyemi

January 2015

Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality in the United Stat...

Ophiopogonin D Reduces Myocardial Ischemia-Reperfusion Injury via Upregulating CYP2J3/EETs in Rats

Xiaoyan Huang
Yuguang Wang
Yi Wang
Liang Yang
Jia Wang
Yue Gao

September 2018

Background/Aims: Epoxyeicosatrienoic acids (EETs) are cytochrome P450 epoxygenase (CYP) metabolites ...

Examining the potential of PGE₂ receptor EP₄ as a neuroprotective target following ischaemic injury

Gibson, Claire
Grubb, Blair
Akram, Asha

January 2013

Ischaemic stroke instigates a series of pathological mechanisms which contribute to injury. Despite ...

Role of Endothelial Soluble Epoxide Hydrolase in Cerebrovascular Function and Ischemic Injury

Zhang, Wenri
Davis, Catherine M.
Edin, Matthew L.
Lee, Craig R.
Zeldin, Darryl C.
Alkayed, Nabil J.

January 2013

Soluble Epoxide Hydrolase (sEH) is a key enzyme in the metabolism and termination of action of epoxy...

Cytochrome P450 2J2 is protective against global cerebral ischemia in transgenic mice

Abstract

Extracted data

Cytochrome P450 2J2 is protective against global cerebral ischemia in transgenic mice

Abstract

Extracted data

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