Comprehensive analysis of dengue virus-specific responses supports an HLA-linked protective role for CD8+ T cells
- Weiskopf, D.
- Angelo, M. A.
- de Azeredo, E. L.
- Sidney, J.
- Greenbaum, J. A.
- Fernando, A. N.
- Broadwater, A.
- Kolla, R. V.
- De Silva, A. D.
- de Silva, A. M.
- Mattia, K. A.
- Doranz, B. J.
- Grey, H. M.
- Shresta, S.
- Peters, B.
- Sette, A.
Publication date
January 2013
DOIAbstract
Dengue virus is the etiologic agent of dengue fever, the most significant mosquito-borne viral disease in humans, affecting over 100 million individuals each year. Currently there is no licensed vaccine or effective antiviral therapy available, and treatment is largely supportive in nature. This study presents a comprehensive analysis of functional T-cell memory against dengue viruses and suggests an HLA-linked protective role for CD8+ T cells. This demonstration of the protective role of T-cell responses points the way forward to identifying robust correlates of protection in natural immunity and vaccination against dengue virus
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