Neurocognition in children with autosomal recessive polycystic kidney disease in the CKiD cohort study

Autosomal recessive polycystic kidney disease (ARPKD) is an inherited disorder characterized by enlarged, cystic kidneys with progressive chronic kidney disease (CKD), systemic hypertension, and congenital hepatic fibrosis. Children with ARPKD can have early onset CKD and severe hypertension, both of which are known to have adverse neurocognitive effects. Objectives of this study were to (1) determine whether ARPKD patients have greater neurocognitive deficits compared to that of children with other causes of CKD, and (2) examine the relative prevalence of hypertension in ARPKD, a known risk factor for neurocognitive dysfunction