The HIV-1-envelope (Env) spike, comprising three gp120 and three gp41 subunits, is a conformational machine that facilitates HIV-1 entry by rearranging from a mature unliganded state, through receptor-bound intermediates, to a postfusion state. As the sole viral antigen on the HIV-1-virion surface, Env is both the target of neutralizing antibodies and a focus of vaccine efforts. Here we report the structure at 3.5-Å resolution for an HIV-1-Env trimer captured in a mature closed state by antibodies PGT122 and 35O22. This structure reveals the prefusion conformation of gp41, indicates rearrangements needed for fusion activation, and defines parameters of immune evasion and immune recognition. Prefusion gp41 encircles N- and C-terminal strands...
The induction by vaccination of broadly neutralizing antibodies (bNAbs) capable of neutralizing vari...
During the entry process, the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env...
The trimeric human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) spike is a mole...
The HIV-1-envelope (Env) spike, comprising three gp120 and three gp41 subunits, is a conformational ...
CAPRISA, 2014.The human immunodeficiency virus type 1 (HIV-1) envelope (Env) spike, comprising three...
Acquired immunodeficiency syndrome (AIDS) and its causal agent, the human immunodeficiency virus 1 (...
SummaryThe HIV-1 envelope (Env) spike contains limited epitopes for broadly neutralizing antibodies ...
The HIV-1 envelope (Env) spike contains limited epitopes for broadly neutralizing antibodies (bNAbs)...
The HIV-1 envelope (Env) glycoprotein binds to host cell receptors to mediate membrane fusion. The p...
The human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer, a membrane-fusing machi...
The induction of broadly HIV-1 neutralizing antibodies (bNAbs) by vaccination is challenging, but un...
HIV-1 broadly neutralizing antibodies are desired for their therapeutic potential and as templates f...
The HIV-1 envelope (Env) spike contains limited epitopes for broadly neutralizing antibodies (bNAbs)...
The HIV-1 envelope (Env) spike contains limited epitopes for broadly neutralizing antibodies (bNAbs)...
The envelope glycoprotein, Env, of human immunodeficiency virus type 1 (HIV-1) mediates viral entry ...
The induction by vaccination of broadly neutralizing antibodies (bNAbs) capable of neutralizing vari...
During the entry process, the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env...
The trimeric human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) spike is a mole...
The HIV-1-envelope (Env) spike, comprising three gp120 and three gp41 subunits, is a conformational ...
CAPRISA, 2014.The human immunodeficiency virus type 1 (HIV-1) envelope (Env) spike, comprising three...
Acquired immunodeficiency syndrome (AIDS) and its causal agent, the human immunodeficiency virus 1 (...
SummaryThe HIV-1 envelope (Env) spike contains limited epitopes for broadly neutralizing antibodies ...
The HIV-1 envelope (Env) spike contains limited epitopes for broadly neutralizing antibodies (bNAbs)...
The HIV-1 envelope (Env) glycoprotein binds to host cell receptors to mediate membrane fusion. The p...
The human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer, a membrane-fusing machi...
The induction of broadly HIV-1 neutralizing antibodies (bNAbs) by vaccination is challenging, but un...
HIV-1 broadly neutralizing antibodies are desired for their therapeutic potential and as templates f...
The HIV-1 envelope (Env) spike contains limited epitopes for broadly neutralizing antibodies (bNAbs)...
The HIV-1 envelope (Env) spike contains limited epitopes for broadly neutralizing antibodies (bNAbs)...
The envelope glycoprotein, Env, of human immunodeficiency virus type 1 (HIV-1) mediates viral entry ...
The induction by vaccination of broadly neutralizing antibodies (bNAbs) capable of neutralizing vari...
During the entry process, the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env...
The trimeric human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) spike is a mole...