Placebo Adherence, Clinical Outcomes, and Mortality in the Womenʼs Health Initiative Randomized Hormone Therapy Trials
- R. Curtis, Jeffrey
- Larson, Joseph C.
- Delzell, Elizabeth
- Brookhart, Maurice Alan
- Cadarette, Suzanne M.
- Chlebowski, Rowan
- Judd, Suzanne
- Safford, Monika
- Solomon, Daniel H.
- LaCroix, Andrea Z.
Publication date
January 2011
DOIAbstract
Medication adherence may be a proxy for healthy behaviors and other factors that affect outcomes. Prior studies of the association between placebo adherence and health outcomes have been limited primarily to men enrolled in clinical trials and cardiovascular disease outcomes. We examined associations between adherence to placebo and the risk of fracture, coronary heart disease, cancer, and all-cause mortality in the two Women’s Health Initiative (WHI) hormone therapy randomized trials
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