Improved kinetics of rIX-FP, a recombinant fusion protein linking factor IX with albumin, in cynomolgus monkeys and hemophilia B dogs: Improved kinetics of rIX-FP
- NOLTE, M. W.
- NICHOLS, T. C.
- MUELLER-COHRS, J.
- MERRICKS, E. P.
- PRAGST, I.
- ZOLLNER, S.
- DICKNEITE, G.
Publication date
January 2012
DOIAbstract
Prophylaxis of hemophilia B, at present, requires multiple infusions of human factor IX (FIX) concentrates per week. A FIX molecule with a prolonged half-life has the potential to greatly improve convenience of, and adherence to, prophylaxis
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