The septic milieu triggers expression of spliced tissue factor mRNA in human platelets: Sepsis induces platelet tissue factor mRNA
- RONDINA, M. T.
- SCHWERTZ, H.
- HARRIS, E. S.
- KRAEMER, B. F.
- CAMPBELL, R. A.
- MACKMAN, N.
- GRISSOM, C. K.
- WEYRICH, A. S.
- ZIMMERMAN, G. A.
Publication date
January 2011
DOIAbstract
Activated platelets have previously-unrecognized mechanisms of post-transcriptional gene expression that may influence hemostasis and inflammation. A novel pathway involves splicing of pre-mRNAs in resting platelets to mature, translatable mRNAs in response to cellular activation
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