Obesity and Risk of Esophageal Adenocarcinoma and Barrett’s Esophagus: A Mendelian Randomization Study

ORIGINAL ARTICLE Body Mass Index, Smoking, and Alcohol and Risks of Barrett’s Esophagus and Esophageal Adenocarcinoma: A UK Prospective Cohort Study

Max Yates
Edward Cheong
Robert Luben
Laszlo Igali
Rebecca Fitzgerald
Kay-tee Khaw
Andrew Hart
M. Yates
E. Cheong
L. Igali
A. Hart
M. Yates
E. Cheong
L. Igali

August 2016

The Author(s) 2014. This article is published with open access at Springerlink.com Background The ti...

Risk of Esophageal Adenocarcinoma Decreases With Height, Based on Consortium Analysis and Confirmed by Mendelian Randomization

Thrift, Aaron P.
Risch, Harvey A.
Onstad, Lynn
Shaheen, Nicholas J.
Casson, Alan G.
Bernstein, Leslie
Corley, Douglas A.
Levine, David M.
Chow, Wong Ho
Reid, Brian J.
Romero, Yvonne
Hardie, Laura J.
Liu, Geoffrey
Wu, Anna H.
Bird, Nigel C.
Gammon, Marilie D.
Ye, Weimin
Whiteman, David C.
Vaughan, Thomas L.

January 2014

Risks for some cancers increase with height. We investigated the relationship between height and ris...

Inverse association between gluteofemoral obesity and risk of Barrett's esophagus in a pooled analysis

Kendall, Bradley J.
Rubenstein, Joel H.
Cook, Michael B.
Vaughan, Thomas L.
Anderson, Lesley A.
Murray, Liam J.
Shaheen, Nicholas J.
Corley, Douglas A.
Chandar, Apoorva K.
Li, Li
Greer, Katarina B.
Chak, Amitabh
El-Serag, Hashem B.
Whiteman, David C.
Thrift, Aaron P.

October 2016

Gluteofemoral obesity (determined by measurement of subcutaneous fat in the hip and thigh regions) c...

Obesity and Risk of Esophageal Adenocarcinoma and Barrett’s Esophagus: A Mendelian Randomization Study

Thrift, Aaron P.
Shaheen, Nicholas J.
Gammon, Marilie D.
Bernstein, Leslie
Reid, Brian J.
Onstad, Lynn
Risch, Harvey A.
Liu, Geoffrey
Bird, Nigel C.
Wu, Anna H.
Corley, Douglas A.
Romero, Yvonne
Chanock, Stephen J.
Chow, Wong-Ho
Casson, Alan G.
Levine, David M.
Zhang, Rui
Ek, Weronica E.
MacGregor, Stuart
Ye, Weimin
Hardie, Laura J.
Vaughan, Thomas L.
Whiteman, David C.

January 2014

Data from observational studies suggest that body mass index (BMI) is causally related to esophageal...

Obesity and risk of esophageal adenocarcinoma and barrett's esophagus: A mendelian randomization study

Thrift, Aaron P.
Shaheen, Nicholas J.
Gammon, Marilie D.
Bernstein, Leslie
Reid, Brian J.
Onstad, Lynn
Risch, Harvey A.
Liu, Geoffrey
Bird, Nigel C.
Wu, Anna H.
Corley, Douglas A.
Romero, Yvonne
Chanock, Stephen J.
Chow, Wong-Ho
Casson, Alan G.
Levine, David M.
Zhang, Rui
Ek, Weronica E.
MacGregor, Stuart
Ye, Weimin
Hardie, Laura J.
Vaughan, Thomas L.
Whiteman, David C.

November 2014

Background Data from observational studies suggest that body mass index (BMI) is causally related to...

Shared genetic etiology of obesity-related traits and Barrett's esophagus/adenocarcinoma: insights from genome-wide association studies

Böhmer, Anne Christin
Hecker, Julian
Schröder, Julia
Gharahkhani, Puya
May, Andrea
Gerges, Christian
Anders, Mario
Becker, Jessica
Hess, Timo
Kreuser, Nicole
Thieme, Rene
Noder, Tania
Venerito, Marino
Veits, Lothar
Schmidt, Thomas
Fuchs, Claudia
Izbicki, Jakob R.
Hölscher, Arnulf H.
Dietrich, Arne
Moulla, Yusef
Lyros, Orestis
Lang, Hauke
Lorenz, Dietmar
Schumacher, Brigitte
Meyershofer, Rupert
Vashist, Yogesh K.
Ott, Katja
Vieth, Michael
Weissmüller, Josef
Moebus, Susanne
Knapp, Michael

February 2020

Background: Obesity is a major risk factor for esophageal adenocarcinoma (EA) and its precursor Barr...

Shared Genetic Etiology of Obesity-Related Traits and Barrett's Esophagus/Adenocarcinoma: Insights from Genome-Wide Association Studies

Böhmer, A.C.
Hecker, J.
Schröder, J.
Gharahkhani, P.
May, A.
Gerges, C.
Anders, M.
Becker, J.
Hess, T.
Kreuser, N.
Thieme, R.
Noder, T.
Venerito, M.
Veits, L.
Schmidt, T.
Fuchs, C.
Izbicki, J.R.
Hölscher, A.H.
Dietrich, A.
Moulla, Y.
Lyros, O.
Lang, H.
Lorenz, D.
Schumacher, B.
Mayershofer, R.
Vashist, Y.
Ott, K.
Vieth, M.
Weismüller, J.
Moebus, S.
Knapp, M.
Neuhaus, H.
Rösch, T.
Ell, C.
Nöthen, M.M.
Whiteman, D.C.
Tomlinson, I.
Jankowski, J.
Fitzgerald, R.C.
Palles, C.
Vaughan, T.L.
Gockel, I.
Thrift, A.P.
Fier, H.
Schumacher, J.

January 2020

BACKGROUND: Obesity is a major risk factor for esophageal adenocarcinoma (EA) and its precursor Barr...

Body mass index, smoking, and alcohol and risks of Barrett’s esophagus and esophageal adenocarcinoma: A UK prospective cohort study

Yates, Max
Cheong, Edward
Luben, Robert
Igali, Laszlo
Fitzgerald, Rebecca
Khaw, Kay-Tee
Hart, Andrew

July 2014

Background The timing of the risk factors cigarette smoking, alcohol and obesity in the development ...

Gastroesophageal reflux does not alter effects of body mass index on risk of esophageal adenocarcinoma

Lagergren, Jesper
Mattsson, Fredrik
Nyrén, Olof

October 2015

Background & Aims: A history of high body mass index (BMI) is strongly associated with risk of esoph...

Published by Blackwell Publishing EDITORIAL Barrett’s Esophagus and Obesity: The Missing

October 2015

Obesity is a recognized risk factor of gastroesophageal reflux disease (GERD) and esophageal adenoca...

Pleiotropic Analysis of Cancer Risk Loci on Esophageal Adenocarcinoma Risk

Lee, Eunjung
Stram, Daniel O.
Ek, Weronica E.
Onstad, Lynn E.
MacGregor, Stuart
Gharahkhani, Puya
Ye, Weimin
Lagergren, Jesper
Shaheen, Nicholas J.
Murray, Liam J.
Hardie, Laura J.
Gammon, Marilie D.
Chow, Wong Ho
Risch, Harvey A.
Corley, Douglas A.
Levine, David M.
Whiteman, David C.
Bernstein, Leslie
Bird, Nigel C.
Vaughan, Thomas L.
Wu, Anna H.

January 2015

Several cancer-associated loci identified from genome-wide association studies (GWAS) have been asso...

Germline Genetic Contributions to Risk for Esophageal Adenocarcinoma, Barrett's Esophagus, and Gastroesophageal Reflux

Ek, W. E.
Levine, D. M.
D'Amato, M.
Pedersen, N. L.
Magnusson, P. K. E.
Bresso, F.
Onstad, L. E.
Schmidt, P. T.
Tornblom, H.
Nordenstedt, H.
Romero, Y.
Chow, W.-H.
Murray, L. J.
Gammon, M. D.
Liu, G.
Bernstein, L.
Casson, A. G.
Risch, H. A.
Shaheen, N. J.
Bird, N. C.
Reid, B. J.
Corley, D. A.
Hardie, L. J.
Ye, W.
Wu, A. H.
Zucchelli, M.
Spector, T. D.
Hysi, P.
Vaughan, T. L.
Whiteman, D. C.
MacGregor, S.

January 2013

Esophageal adenocarcinoma (EA) is an increasingly common cancer with poor survival. Barrett’s esopha...

Interactions Between Genetic Variants and Environmental Factors Affect Risk of Esophageal Adenocarcinoma and Barrett’s Esophagus

Dong, J
Levine, DM
Buas, MF
Zhang, R
Onstad, L
Fitzgerald, RC
Stomach and Oesophageal Cancer Study (SOCS) Consortium
Corley, DA
Shaheen, NJ
Lagergren, J
Hardie, LJ
Reid, BJ
Iyer, PG
Risch, HA
Caldas, C
Caldas, I
Pharoah, PD
Liu, G
Gammon, MD
Chow, W-H
Bernstein, L
Bird, NC
Ye, W
Wu, AH
Anderson, LA
MacGregor, S
Whiteman, DC
Vaughan, TL
Thrift, AP

October 2018

Background & Aims: Genome-wide association studies (GWAS) have identified more than 20 susceptibilit...

Interactions Between Genetic Variants and Environmental Factors Affect Risk of Esophageal Adenocarcinoma and Barrett's Esophagus.

Dong, Jing
Levine, David M
Buas, Matthew F
Zhang, Rui
Onstad, Lynn
Fitzgerald, Rebecca
Stomach and Oesophageal Cancer Study (SOCS) Consortium
Corley, Douglas A
Shaheen, Nicholas J
Lagergren, Jesper
Hardie, Laura J
Reid, Brian J
Iyer, Prasad G
Risch, Harvey A
Caldas, Carlos
Caldas, Isabel
Pharoah, Paul
Liu, Geoffrey
Gammon, Marilie D
Chow, Wong-Ho
Bernstein, Leslie
Bird, Nigel C
Ye, Weimin
Wu, Anna H
Anderson, Lesley A
MacGregor, Stuart
Whiteman, David C
Vaughan, Thomas L
Thrift, Aaron P

October 2018

BACKGROUND & AIMS: Genome-wide association studies (GWAS) have identified more than 20 susceptibilit...

The Epidemiology of Esophageal Adenocarcinoma

Coleman, Helen G.
Xie, Shao-Hua
Lagergren, Jesper

January 2018

The incidence of esophageal adenocarcinoma (EAC) has increased in many Western countries, and is hig...

ORIGINAL ARTICLE Body Mass Index, Smoking, and Alcohol and Risks of Barrett’s Esophagus and Esophageal Adenocarcinoma: A UK Prospective Cohort Study

Max Yates
Edward Cheong
Robert Luben
Laszlo Igali
Rebecca Fitzgerald
Kay-tee Khaw
Andrew Hart
M. Yates
E. Cheong
L. Igali
A. Hart
M. Yates
E. Cheong
L. Igali

August 2016

The Author(s) 2014. This article is published with open access at Springerlink.com Background The ti...

Risk of Esophageal Adenocarcinoma Decreases With Height, Based on Consortium Analysis and Confirmed by Mendelian Randomization

Thrift, Aaron P.
Risch, Harvey A.
Onstad, Lynn
Shaheen, Nicholas J.
Casson, Alan G.
Bernstein, Leslie
Corley, Douglas A.
Levine, David M.
Chow, Wong Ho
Reid, Brian J.
Romero, Yvonne
Hardie, Laura J.
Liu, Geoffrey
Wu, Anna H.
Bird, Nigel C.
Gammon, Marilie D.
Ye, Weimin
Whiteman, David C.
Vaughan, Thomas L.

January 2014

Risks for some cancers increase with height. We investigated the relationship between height and ris...

Inverse association between gluteofemoral obesity and risk of Barrett's esophagus in a pooled analysis

Kendall, Bradley J.
Rubenstein, Joel H.
Cook, Michael B.
Vaughan, Thomas L.
Anderson, Lesley A.
Murray, Liam J.
Shaheen, Nicholas J.
Corley, Douglas A.
Chandar, Apoorva K.
Li, Li
Greer, Katarina B.
Chak, Amitabh
El-Serag, Hashem B.
Whiteman, David C.
Thrift, Aaron P.

October 2016

Gluteofemoral obesity (determined by measurement of subcutaneous fat in the hip and thigh regions) c...

Obesity and Risk of Esophageal Adenocarcinoma and Barrett’s Esophagus: A Mendelian Randomization Study

Thrift, Aaron P.
Shaheen, Nicholas J.
Gammon, Marilie D.
Bernstein, Leslie
Reid, Brian J.
Onstad, Lynn
Risch, Harvey A.
Liu, Geoffrey
Bird, Nigel C.
Wu, Anna H.
Corley, Douglas A.
Romero, Yvonne
Chanock, Stephen J.
Chow, Wong-Ho
Casson, Alan G.
Levine, David M.
Zhang, Rui
Ek, Weronica E.
MacGregor, Stuart
Ye, Weimin
Hardie, Laura J.
Vaughan, Thomas L.
Whiteman, David C.

January 2014

Data from observational studies suggest that body mass index (BMI) is causally related to esophageal...

Obesity and risk of esophageal adenocarcinoma and barrett's esophagus: A mendelian randomization study

Thrift, Aaron P.
Shaheen, Nicholas J.
Gammon, Marilie D.
Bernstein, Leslie
Reid, Brian J.
Onstad, Lynn
Risch, Harvey A.
Liu, Geoffrey
Bird, Nigel C.
Wu, Anna H.
Corley, Douglas A.
Romero, Yvonne
Chanock, Stephen J.
Chow, Wong-Ho
Casson, Alan G.
Levine, David M.
Zhang, Rui
Ek, Weronica E.
MacGregor, Stuart
Ye, Weimin
Hardie, Laura J.
Vaughan, Thomas L.
Whiteman, David C.

November 2014

Background Data from observational studies suggest that body mass index (BMI) is causally related to...

Shared genetic etiology of obesity-related traits and Barrett's esophagus/adenocarcinoma: insights from genome-wide association studies

Böhmer, Anne Christin
Hecker, Julian
Schröder, Julia
Gharahkhani, Puya
May, Andrea
Gerges, Christian
Anders, Mario
Becker, Jessica
Hess, Timo
Kreuser, Nicole
Thieme, Rene
Noder, Tania
Venerito, Marino
Veits, Lothar
Schmidt, Thomas
Fuchs, Claudia
Izbicki, Jakob R.
Hölscher, Arnulf H.
Dietrich, Arne
Moulla, Yusef
Lyros, Orestis
Lang, Hauke
Lorenz, Dietmar
Schumacher, Brigitte
Meyershofer, Rupert
Vashist, Yogesh K.
Ott, Katja
Vieth, Michael
Weissmüller, Josef
Moebus, Susanne
Knapp, Michael

February 2020

Background: Obesity is a major risk factor for esophageal adenocarcinoma (EA) and its precursor Barr...

Shared Genetic Etiology of Obesity-Related Traits and Barrett's Esophagus/Adenocarcinoma: Insights from Genome-Wide Association Studies

Böhmer, A.C.
Hecker, J.
Schröder, J.
Gharahkhani, P.
May, A.
Gerges, C.
Anders, M.
Becker, J.
Hess, T.
Kreuser, N.
Thieme, R.
Noder, T.
Venerito, M.
Veits, L.
Schmidt, T.
Fuchs, C.
Izbicki, J.R.
Hölscher, A.H.
Dietrich, A.
Moulla, Y.
Lyros, O.
Lang, H.
Lorenz, D.
Schumacher, B.
Mayershofer, R.
Vashist, Y.
Ott, K.
Vieth, M.
Weismüller, J.
Moebus, S.
Knapp, M.
Neuhaus, H.
Rösch, T.
Ell, C.
Nöthen, M.M.
Whiteman, D.C.
Tomlinson, I.
Jankowski, J.
Fitzgerald, R.C.
Palles, C.
Vaughan, T.L.
Gockel, I.
Thrift, A.P.
Fier, H.
Schumacher, J.

January 2020

BACKGROUND: Obesity is a major risk factor for esophageal adenocarcinoma (EA) and its precursor Barr...

Body mass index, smoking, and alcohol and risks of Barrett’s esophagus and esophageal adenocarcinoma: A UK prospective cohort study

Yates, Max
Cheong, Edward
Luben, Robert
Igali, Laszlo
Fitzgerald, Rebecca
Khaw, Kay-Tee
Hart, Andrew

July 2014

Background The timing of the risk factors cigarette smoking, alcohol and obesity in the development ...

Gastroesophageal reflux does not alter effects of body mass index on risk of esophageal adenocarcinoma

Lagergren, Jesper
Mattsson, Fredrik
Nyrén, Olof

October 2015

Background & Aims: A history of high body mass index (BMI) is strongly associated with risk of esoph...

Published by Blackwell Publishing EDITORIAL Barrett’s Esophagus and Obesity: The Missing

October 2015

Obesity is a recognized risk factor of gastroesophageal reflux disease (GERD) and esophageal adenoca...

Pleiotropic Analysis of Cancer Risk Loci on Esophageal Adenocarcinoma Risk

Lee, Eunjung
Stram, Daniel O.
Ek, Weronica E.
Onstad, Lynn E.
MacGregor, Stuart
Gharahkhani, Puya
Ye, Weimin
Lagergren, Jesper
Shaheen, Nicholas J.
Murray, Liam J.
Hardie, Laura J.
Gammon, Marilie D.
Chow, Wong Ho
Risch, Harvey A.
Corley, Douglas A.
Levine, David M.
Whiteman, David C.
Bernstein, Leslie
Bird, Nigel C.
Vaughan, Thomas L.
Wu, Anna H.

January 2015

Several cancer-associated loci identified from genome-wide association studies (GWAS) have been asso...

Germline Genetic Contributions to Risk for Esophageal Adenocarcinoma, Barrett's Esophagus, and Gastroesophageal Reflux

Ek, W. E.
Levine, D. M.
D'Amato, M.
Pedersen, N. L.
Magnusson, P. K. E.
Bresso, F.
Onstad, L. E.
Schmidt, P. T.
Tornblom, H.
Nordenstedt, H.
Romero, Y.
Chow, W.-H.
Murray, L. J.
Gammon, M. D.
Liu, G.
Bernstein, L.
Casson, A. G.
Risch, H. A.
Shaheen, N. J.
Bird, N. C.
Reid, B. J.
Corley, D. A.
Hardie, L. J.
Ye, W.
Wu, A. H.
Zucchelli, M.
Spector, T. D.
Hysi, P.
Vaughan, T. L.
Whiteman, D. C.
MacGregor, S.

January 2013

Esophageal adenocarcinoma (EA) is an increasingly common cancer with poor survival. Barrett’s esopha...

Interactions Between Genetic Variants and Environmental Factors Affect Risk of Esophageal Adenocarcinoma and Barrett’s Esophagus

Dong, J
Levine, DM
Buas, MF
Zhang, R
Onstad, L
Fitzgerald, RC
Stomach and Oesophageal Cancer Study (SOCS) Consortium
Corley, DA
Shaheen, NJ
Lagergren, J
Hardie, LJ
Reid, BJ
Iyer, PG
Risch, HA
Caldas, C
Caldas, I
Pharoah, PD
Liu, G
Gammon, MD
Chow, W-H
Bernstein, L
Bird, NC
Ye, W
Wu, AH
Anderson, LA
MacGregor, S
Whiteman, DC
Vaughan, TL
Thrift, AP

October 2018

Background & Aims: Genome-wide association studies (GWAS) have identified more than 20 susceptibilit...

Interactions Between Genetic Variants and Environmental Factors Affect Risk of Esophageal Adenocarcinoma and Barrett's Esophagus.

Dong, Jing
Levine, David M
Buas, Matthew F
Zhang, Rui
Onstad, Lynn
Fitzgerald, Rebecca
Stomach and Oesophageal Cancer Study (SOCS) Consortium
Corley, Douglas A
Shaheen, Nicholas J
Lagergren, Jesper
Hardie, Laura J
Reid, Brian J
Iyer, Prasad G
Risch, Harvey A
Caldas, Carlos
Caldas, Isabel
Pharoah, Paul
Liu, Geoffrey
Gammon, Marilie D
Chow, Wong-Ho
Bernstein, Leslie
Bird, Nigel C
Ye, Weimin
Wu, Anna H
Anderson, Lesley A
MacGregor, Stuart
Whiteman, David C
Vaughan, Thomas L
Thrift, Aaron P

October 2018

BACKGROUND & AIMS: Genome-wide association studies (GWAS) have identified more than 20 susceptibilit...

The Epidemiology of Esophageal Adenocarcinoma

Coleman, Helen G.
Xie, Shao-Hua
Lagergren, Jesper

January 2018

The incidence of esophageal adenocarcinoma (EAC) has increased in many Western countries, and is hig...

ORIGINAL ARTICLE Body Mass Index, Smoking, and Alcohol and Risks of Barrett’s Esophagus and Esophageal Adenocarcinoma: A UK Prospective Cohort Study

Max Yates
Edward Cheong
Robert Luben
Laszlo Igali
Rebecca Fitzgerald
Kay-tee Khaw
Andrew Hart
M. Yates
E. Cheong
L. Igali
A. Hart
M. Yates
E. Cheong
L. Igali

August 2016

The Author(s) 2014. This article is published with open access at Springerlink.com Background The ti...

Risk of Esophageal Adenocarcinoma Decreases With Height, Based on Consortium Analysis and Confirmed by Mendelian Randomization

Thrift, Aaron P.
Risch, Harvey A.
Onstad, Lynn
Shaheen, Nicholas J.
Casson, Alan G.
Bernstein, Leslie
Corley, Douglas A.
Levine, David M.
Chow, Wong Ho
Reid, Brian J.
Romero, Yvonne
Hardie, Laura J.
Liu, Geoffrey
Wu, Anna H.
Bird, Nigel C.
Gammon, Marilie D.
Ye, Weimin
Whiteman, David C.
Vaughan, Thomas L.

January 2014

Risks for some cancers increase with height. We investigated the relationship between height and ris...

Inverse association between gluteofemoral obesity and risk of Barrett's esophagus in a pooled analysis

Kendall, Bradley J.
Rubenstein, Joel H.
Cook, Michael B.
Vaughan, Thomas L.
Anderson, Lesley A.
Murray, Liam J.
Shaheen, Nicholas J.
Corley, Douglas A.
Chandar, Apoorva K.
Li, Li
Greer, Katarina B.
Chak, Amitabh
El-Serag, Hashem B.
Whiteman, David C.
Thrift, Aaron P.

October 2016

Gluteofemoral obesity (determined by measurement of subcutaneous fat in the hip and thigh regions) c...

Obesity and Risk of Esophageal Adenocarcinoma and Barrett’s Esophagus: A Mendelian Randomization Study

Abstract

Extracted data

Obesity and Risk of Esophageal Adenocarcinoma and Barrett’s Esophagus: A Mendelian Randomization Study

Abstract

Extracted data

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