Mechanistic Analysis of Gold(I)-Catalyzed Intramolecular Allene Hydroalkoxylation Reveals an Off-Cycle Bis(gold) Vinyl Species and Reversible C–O Bond Formation
- Brown, Timothy J.
- Weber, Dieter
- Gagné, Michel R.
- Widenhoefer, Ross A.
- ience Center, Duke University, Durham, North Carolina 27708-0346,rUnited States
Publication date
January 2012
DOIAbstract
Mechanistic investigation of gold(I)-catalyzed intramolecular allene hydroalkoxylation established a mechanism involving rapid and reversible C–O bond formation followed by turnover-limiting protodeauration from a mono(gold) vinyl complex. This on-cycle pathway competes with catalyst aggregation and formation of an off-cycle bis(gold) vinyl complex
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