Pathologic Findings at Risk-Reducing Salpingo-Oophorectomy: Primary Results From Gynecologic Oncology Group Trial GOG-0199
- Sherman, Mark E.
- Piedmonte, Marion
- Mai, Phuong L.
- Ioffe, Olga B.
- Ronnett, Brigitte M.
- Van Le, Linda
- Ivanov, Iouri
- Bell, Maria C.
- Blank, Stephanie V.
- DiSilvestro, Paul
- Hamilton, Chad A.
- Tewari, Krishnansu S.
- Wakeley, Katie
- Kauff, Noah D.
- Yamada, S. Diane
- Rodriguez, Gustavo
- Skates, Steven J.
- Alberts, David S.
- Walker, Joan L.
- Minasian, Lori
- Lu, Karen
- Greene, Mark H.
Publication date
January 2014
DOIAbstract
Risk-reducing salpingo-oophorectomy (RRSO) lowers mortality from ovarian/tubal and breast cancers among BRCA1/2 mutation carriers. Uncertainties persist regarding potential benefits of RRSO among high-risk noncarriers, optimal surgical age, and anatomic origin of clinically occult cancers detected at surgery. To address these topics, we analyzed surgical treatment arm results from Gynecologic Oncology Group Protocol-0199 (GOG-0199), the National Ovarian Cancer Prevention and Early Detection Study
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