Relationship Between Galectin-3 Levels and Mineralocorticoid Receptor Antagonist Use in Heart Failure: Analysis From HF-ACTION
- Fiuzat, Mona
- Schulte, Phillip J.
- Felker, Michael
- Ahmad, Tariq
- Neely, Megan
- Adams, Kirkwood F.
- Donahue, Mark P.
- Kraus, William E.
- Piña, Ileana L.
- Whellan, David J.
- O’Connor, Christopher M.
Publication date
January 2014
DOIAbstract
Galectin-3 (Gal-3) is a marker of myocardial fibrosis, and elevated levels are associated with adverse outcomes. Mineralocorticoid receptor antagonists (MRA) modulate cardiac fibrosis in HF patients, and have been shown to improve long term outcomes. We examined whether treatment effects from MRA use differed by Gal-3 levels in ambulatory heart failure patients enrolled in the HF-ACTION study
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