Global DNA Methylation, Measured by the Luminometric Methylation Assay (LUMA), Associates with Postmenopausal Breast Cancer in Non-Obese and Physically Active Women
- McCullough, Lauren E.
- Chen, Jia
- White, Alexandra J.
- Xu, Xinran
- Cho, Yoon Hee
- Bradshaw, Patrick T.
- Eng, Sybil M.
- Teitelbaum, Susan L.
- Terry, Mary Beth
- Garbowski, Gail
- Neugut, Alfred I.
- Hibshoosh, Hanina
- Santella, Regina M.
- Gammon, Marilie D.
Publication date
January 2015
DOIAbstract
Introduction: Little is known about how modifiable lifestyle factors interact with the epigenome to influence disease. Body mass index (BMI, weight kg/height m2) and physical activity are associated with postmenopausal breast cancer, but the mechanisms are not well-understood. We hypothesized that BMI or physical activity may modify the association between markers of global DNA methylation and postmenopausal breast cancer risk
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