Rare and Coding Region Genetic Variants Associated With Risk of Ischemic Stroke: The NHLBI Exome Sequence Project
- Auer, Paul L.
- Nalls, Mike
- Meschia, James F.
- Worrall, Bradford B.
- Longstreth, W. T.
- Seshadri, Sudha
- Kooperberg, Charles
- Burger, Kathleen M.
- Carlson, Christopher S.
- Carty, Cara L.
- Chen, Wei-Min
- Cupples, L. Adrienne
- DeStefano, Anita L.
- Fornage, Myriam
- Hardy, John
- Hsu, Li
- Jackson, Rebecca D.
- Jarvik, Gail P.
- Kim, Daniel S.
- Lakshminarayan, Kamakshi
- Lange, Leslie A.
- Manichaikul, Ani
- Quinlan, Aaron R.
- Singleton, Andrew B.
- Thornton, Timothy A.
- Nickerson, Deborah A.
- Peters, Ulrike
- Rich, Stephen S.
Publication date
January 2015
DOIAbstract
Stroke is the second leading cause of death and the third leading cause of years of life lost. Genetic factors contribute to stroke prevalence, and candidate gene and genome-wide association studies (GWAS) have identified variants associated with ischemic stroke risk. These variants often have small effects without obvious biological significance. Exome sequencing may discover predicted protein-altering variants with a potentially large effect on ischemic stroke risk
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