Regulatory T Cells and the Risk of CMV End-Organ Disease in Patients With AIDS
- Weinberg, Adriana
- Bosch, Ronald
- Bennett, Kara
- Tovar-Salazar, Adriana
- Benson, Constance A.
- Collier, Ann C.
- Zolopa, Andrew
- Gulick, Roy M.
- Wohl, David
- Polsky, Bruce
- Erice, Alejo
- Jacobson, Mark A.
Publication date
January 2014
DOIAbstract
Cytomegalovirus (CMV)-specific T-cell effectors (CMV-Teff) protect against CMV end-organ disease (EOD). In HIV-infected individuals, their numbers and function vary with CD4+ cell numbers and HIV load. The role of regulatory T cells (Treg) in CMV-EOD has not been extensively studied. We investigated the contribution of Treg and Teff towards CMV-EOD in HIV-infected individuals independently of CD4+ cell numbers and HIV load and controlling for CMV reactivations
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