Rationale and design of theguide-it study: Guiding evidence based therapy usingbiomarker intensified treatment inheart failure
- Felker, G. Michael
- Ahmad, Tariq
- Anstrom, Kevin J.
- Adams, Kirkwood F.
- Cooper, Lawton S.
- Ezekowitz, Justin A.
- Fiuzat, Mona
- Houston-Miller, Nancy
- Januzzi, James L.
- Leifer, Eric S.
- Mark, Daniel B.
- Desvigne-Nickens, Patrice
- Paynter, Gayle
- Piña, Ileana L.
- Whellan, David J.
- O’Connor, Christopher M.
Publication date
January 2014
DOIAbstract
The Guiding Evidence Based Therapy Using Biomarker Intensified Treatment (GUIDE-IT) Study was designed to determine the safety, efficacy, and cost effectiveness of a strategy based on achieving and maintaining an amino-terminal pro-B-type natriuretic peptide (NT-proBNP) target of less than 1000 pg/mL, compared with usual care in high risk systolic heart failure (HF) patients
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