The Use of Normal Tissue Complication Probability (NTCP) Models in the Clinic
- Marks, Lawrence B.
- Yorke, Ellen D.
- Jackson, Andrew
- Ten Haken, Randall K.
- Constine, Louis S.
- Eisbruch, Avraham
- Bentzen, Søren M.
- Nam, Jiho
- Deasy, Joseph O.
Publication date
January 2010
DOIAbstract
The QUANTEC (quantitative analysis of normal tissue effects in the clinic) review summarizes the currently-available three dimensional dose/volume/outcome data to update and refine the normal tissue dose/volume tolerance guidelines provided by the classic “Emami” paper (IJROBP 21:109, 1991). A “clinician’s view” on using the QUANTEC information in a responsible manner is presented along with a description of the most commonly-used normal tissue complication probability (NTCP) models. A summary of organ-specific dose/volume/outcome data, based on the QUANTEC reviews, is included
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