Heritability and Preliminary Genome-Wide Linkage Analysis of Arsenic Metabolites in Urine

Efficient arsenic metabolism--the AS3MT haplotype is associated with DNA methylation and expression of multiple genes around AS3MT.

Karin S Engström
Mohammad Bakhtiar Hossain
Martin Lauss
Sultan Ahmed
Rubhana Raqib
Marie Vahter
Karin Broberg

Arsenic is a very potent toxicant. One major susceptibility factor for arsenic-related toxicity is t...

Locus-Specific Differential DNA Methylation and Urinary Arsenic: An Epigenome-Wide Association Study in Blood among Adults with Low-to-Moderate Arsenic Exposure

Bozack, Anne K
Domingo-Relloso, Arce
Haack, Karin
Gamble, Mary V
Tellez-Plaza, Maria
Umans, Jason G
Best, Lyle G
Yracheta, Joseph
Gribble, Matthew O
Cardenas, Andres
Francesconi, Kevin A
Goessler, Walter
Tang, Wan-Yee
Fallin, M Daniele
Cole, Shelley A
Navas-Acien, Ana

June 2020

Background: Chronic exposure to arsenic (As), a human toxicant and carcinogen, remains a global publ...

Genetic variation in Glutathione S-Transferase Omega-1, Arsenic Methyltransferase and Methylene-tetrahydrofolate Reductase, arsenic exposure and bladder cancer: a case–control study

Beebe-Dimmer, Jennifer L
Iyer, Priyanka T
Nriagu, Jerome O
Keele, Greg R
Mehta, Shilpin
Meliker, Jaymie R
Lange, Ethan M
Schwartz, Ann G
Zuhlke, Kimberly A
Schottenfeld, David
Cooney, Kathleen A

January 2012

Abstract Background Ingestion of groundwater with high concentrations of inorganic arsenic has been ...

Heritability and Preliminary Genome-Wide Linkage Analysis of Arsenic Metabolites in Urine

Tellez-Plaza, Maria
Gribble, Matthew O.
Voruganti, V. Saroja
Francesconi, Kevin A.
Goessler, Walter
Umans, Jason G.
Silbergeld, Ellen K.
Guallar, Eliseo
Franceschini, Nora
North, Kari E.
Kao, Wen H.
MacCluer, Jean W.
Cole, Shelley A.
Navas-Acien, Ana

January 2013

Background: Arsenic (III) methyltransferase (AS3MT) has been related to urine arsenic metabolites in...

Linkage Analysis of Urine Arsenic Species Patterns in the Strong Heart Family Study

Gribble, Matthew O.
Voruganti, Venkata Saroja
Cole, Shelley A.
Haack, Karin
Balakrishnan, Poojitha
Laston, Sandra L.
Tellez-Plaza, Maria
Francesconi, Kevin A.
Goessler, Walter
Umans, Jason G.
Thomas, Duncan C.
Gilliland, Frank
North, Kari E.
Franceschini, Nora
Navas-Acien, Ana

January 2015

Arsenic toxicokinetics are important for disease risks in exposed populations, but genetic determina...

Arsenic metabolism is influenced by polymorphisms in genes involved in one-carbon metabolism and reduction reactions.

Engström, Karin
Nermell, Barbro
Concha, Gabriela
Strömberg, Ulf
Vahter, Marie
Broberg Palmgren, Karin

January 2009

OBJECTIVES: The susceptibility to arsenic (As)-induced diseases differs greatly between individuals,...

Polymorphisms in Arsenic(+III)methyltransferase (AS3MT) Predict Gene Expression of AS3MT as well as Arsenic Metabolism.

Engström, Karin
Vahter, Marie
Jurkovic Mlakar, Simona
Concha, Gabriela
Nermell, Barbro
Raqib, Rubhana
Cardozo, Alejandro
Broberg Palmgren, Karin

January 2011

Background: Arsenic is mono- (MMA) and dimethylated (DMA) in humans and the methylation pattern demo...

Association of AS3MT polymorphisms and the risk of premalignant arsenic skin lesions

Valenzuela, Olga L.
Drobná, Zuzana
Hernández-Castellanos, Erika
Sánchez-Peña, Luz C.
García-Vargas, Gonzalo G.
Borja-Aburto, Víctor H.
Stýblo, Miroslav
Del Razo, Luz M.

January 2009

Exposure to naturally occurring inorganic arsenic (iAs), primarily from contaminated drinking water,...

Genetic polymorphisms influencing arsenic metabolism: evidence from Argentina.

Engström, Karin
Broberg Palmgren, Karin
Concha, Gabriela
Nermell, Barbro
Warholm, Margareta
Vahter, Marie

January 2007

The susceptibility to arsenic-induced diseases differs greatly between individuals, possibly due to ...

Genetic variation in Glutathione S-Transferase Omega-1, Arsenic Methyltransferase and Methylene-tetrahydrofolate Reductase, arsenic exposure and bladder cancer: a case-control study

Beebe-Dimmer, Jennifer L
Iyer, Priyanka T
Nriagu, Jerome O
Keele, Greg R
Mehta, Shilpin
Meliker, Jaymie R
Lange, Ethan
Schwartz, Ann G
Zuhlke, Kimberly A
Schottenfeld, David
Cooney, Kathleen A

June 2012

Background Ingestion of groundwater with high concentrations of inorganic arsenic has been linked to...

Association Between Variants in Arsenic (+3 Oxidation State) Methyltranserase ( AS3MT ) and Urinary Metabolites of Inorganic Arsenic: Role of Exposure Level

Xu, Xiaofan
Drobná, Zuzana
Voruganti, V. Saroja
Barron, Keri
González-Horta, Carmen
Sánchez-Ramírez, Blanca
Ballinas-Casarrubias, Lourdes
Cerón, Roberto Hernández
Morales, Damián Viniegra
Terrazas, Francisco A. Baeza
Ishida, María C.
Gutiérrez-Torres, Daniela S.
Saunders, R. Jesse
Crandell, Jamie
Fry, Rebecca C.
Loomis, Dana
García-Vargas, Gonzalo G.
Del Razo, Luz M.
Stỳblo, Miroslav
Mendez, Michelle A.

January 2016

Variants in AS3MT, the gene encoding arsenic (+3 oxidation state) methyltranserase, have been shown ...

Efficient Arsenic Metabolism — The AS3MT Haplotype Is Associated with DNA Methylation and Expression of Multiple Genes Around AS3MT

Karin S. Engström (102997)
Mohammad Bakhtiar Hossain (102999)
Martin Lauss (103001)
Sultan Ahmed (103003)
Rubhana Raqib (103005)
Marie Vahter (17728)
Karin Broberg (103007)

January 2013

<div>Arsenic is a very potent toxicant. One major susceptibility factor for arsenic-related toxic...

Genome-Wide Association Study Identifies Chromosome 10q24.32 Variants Associated with Arsenic Metabolism and Toxicity Phenotypes in Bangladesh

Pierce, Brandon L.
Kibriya, Muhammad G.
Tong, Lin
Jasmine, Farzana
Argos, Maria
Roy, Shantanu
Paul-Brutus, Rachelle
Rahaman, Ronald
Rakibuz-Zaman, Muhammad
Parvez, Faruque
Ahmed, Alauddin
Quasem, Iftekhar
Hore, Samar K.
Alam, Shafiul
Islam, Tariqul
Slavkovich, Vesna
Gamble, Mary V.
Yunus, Md
Rahman, Mahfuzar
Baron, John A.
Graziano, Joseph H.
Ahsan, Habibul

January 2012

Arsenic contamination of drinking water is a major public health issue in many countries, increasing...

DETERMINANTS OF INTERINDIVIDUAL VARIABILITY IN ARSENIC SECONDARY METHYLATION EFFICIENCY IN A POPULATION FROM NORTHWEST MEXICO

Gomez Rubio, Paulina
Gomez Rubio, Paulina

January 2011

Chronic environmental exposure to inorganic arsenic is widely associated with human disease. Low hum...

Association of Cardiometabolic Genes with Arsenic Metabolism Biomarkers in American Indian Communities: The Strong Heart Family Study (SHFS)

Balakrishnan, Poojitha
Vaidya, Dhananjay
Franceschini, Nora
Saroja Voruganti,
Gribble, Matthew O.
Haack, Karin
Laston, Sandra
Umans, Jason G.
Francesconi, Kevin A.
Goessler, Walter
North, Kari E.
Lee, Elisa
Yracheta, Joseph
Best, Lyle G.
Maccluer, Jean W.
Kent, Jack
Cole, Shelley A.
Navas-Acien, Ana

January 2017

BACKGROUND: Metabolism of inorganic arsenic (iAs) is subject to inter-individual variability, which ...

Efficient arsenic metabolism--the AS3MT haplotype is associated with DNA methylation and expression of multiple genes around AS3MT.

Karin S Engström
Mohammad Bakhtiar Hossain
Martin Lauss
Sultan Ahmed
Rubhana Raqib
Marie Vahter
Karin Broberg

Arsenic is a very potent toxicant. One major susceptibility factor for arsenic-related toxicity is t...

Locus-Specific Differential DNA Methylation and Urinary Arsenic: An Epigenome-Wide Association Study in Blood among Adults with Low-to-Moderate Arsenic Exposure

Bozack, Anne K
Domingo-Relloso, Arce
Haack, Karin
Gamble, Mary V
Tellez-Plaza, Maria
Umans, Jason G
Best, Lyle G
Yracheta, Joseph
Gribble, Matthew O
Cardenas, Andres
Francesconi, Kevin A
Goessler, Walter
Tang, Wan-Yee
Fallin, M Daniele
Cole, Shelley A
Navas-Acien, Ana

June 2020

Background: Chronic exposure to arsenic (As), a human toxicant and carcinogen, remains a global publ...

Genetic variation in Glutathione S-Transferase Omega-1, Arsenic Methyltransferase and Methylene-tetrahydrofolate Reductase, arsenic exposure and bladder cancer: a case–control study

Beebe-Dimmer, Jennifer L
Iyer, Priyanka T
Nriagu, Jerome O
Keele, Greg R
Mehta, Shilpin
Meliker, Jaymie R
Lange, Ethan M
Schwartz, Ann G
Zuhlke, Kimberly A
Schottenfeld, David
Cooney, Kathleen A

January 2012

Abstract Background Ingestion of groundwater with high concentrations of inorganic arsenic has been ...

Heritability and Preliminary Genome-Wide Linkage Analysis of Arsenic Metabolites in Urine

Tellez-Plaza, Maria
Gribble, Matthew O.
Voruganti, V. Saroja
Francesconi, Kevin A.
Goessler, Walter
Umans, Jason G.
Silbergeld, Ellen K.
Guallar, Eliseo
Franceschini, Nora
North, Kari E.
Kao, Wen H.
MacCluer, Jean W.
Cole, Shelley A.
Navas-Acien, Ana

January 2013

Background: Arsenic (III) methyltransferase (AS3MT) has been related to urine arsenic metabolites in...

Linkage Analysis of Urine Arsenic Species Patterns in the Strong Heart Family Study

Gribble, Matthew O.
Voruganti, Venkata Saroja
Cole, Shelley A.
Haack, Karin
Balakrishnan, Poojitha
Laston, Sandra L.
Tellez-Plaza, Maria
Francesconi, Kevin A.
Goessler, Walter
Umans, Jason G.
Thomas, Duncan C.
Gilliland, Frank
North, Kari E.
Franceschini, Nora
Navas-Acien, Ana

January 2015

Arsenic toxicokinetics are important for disease risks in exposed populations, but genetic determina...

Arsenic metabolism is influenced by polymorphisms in genes involved in one-carbon metabolism and reduction reactions.

Engström, Karin
Nermell, Barbro
Concha, Gabriela
Strömberg, Ulf
Vahter, Marie
Broberg Palmgren, Karin

January 2009

OBJECTIVES: The susceptibility to arsenic (As)-induced diseases differs greatly between individuals,...

Polymorphisms in Arsenic(+III)methyltransferase (AS3MT) Predict Gene Expression of AS3MT as well as Arsenic Metabolism.

Engström, Karin
Vahter, Marie
Jurkovic Mlakar, Simona
Concha, Gabriela
Nermell, Barbro
Raqib, Rubhana
Cardozo, Alejandro
Broberg Palmgren, Karin

January 2011

Background: Arsenic is mono- (MMA) and dimethylated (DMA) in humans and the methylation pattern demo...

Association of AS3MT polymorphisms and the risk of premalignant arsenic skin lesions

Valenzuela, Olga L.
Drobná, Zuzana
Hernández-Castellanos, Erika
Sánchez-Peña, Luz C.
García-Vargas, Gonzalo G.
Borja-Aburto, Víctor H.
Stýblo, Miroslav
Del Razo, Luz M.

January 2009

Exposure to naturally occurring inorganic arsenic (iAs), primarily from contaminated drinking water,...

Genetic polymorphisms influencing arsenic metabolism: evidence from Argentina.

Engström, Karin
Broberg Palmgren, Karin
Concha, Gabriela
Nermell, Barbro
Warholm, Margareta
Vahter, Marie

January 2007

The susceptibility to arsenic-induced diseases differs greatly between individuals, possibly due to ...

Genetic variation in Glutathione S-Transferase Omega-1, Arsenic Methyltransferase and Methylene-tetrahydrofolate Reductase, arsenic exposure and bladder cancer: a case-control study

Beebe-Dimmer, Jennifer L
Iyer, Priyanka T
Nriagu, Jerome O
Keele, Greg R
Mehta, Shilpin
Meliker, Jaymie R
Lange, Ethan
Schwartz, Ann G
Zuhlke, Kimberly A
Schottenfeld, David
Cooney, Kathleen A

June 2012

Background Ingestion of groundwater with high concentrations of inorganic arsenic has been linked to...

Association Between Variants in Arsenic (+3 Oxidation State) Methyltranserase ( AS3MT ) and Urinary Metabolites of Inorganic Arsenic: Role of Exposure Level

Xu, Xiaofan
Drobná, Zuzana
Voruganti, V. Saroja
Barron, Keri
González-Horta, Carmen
Sánchez-Ramírez, Blanca
Ballinas-Casarrubias, Lourdes
Cerón, Roberto Hernández
Morales, Damián Viniegra
Terrazas, Francisco A. Baeza
Ishida, María C.
Gutiérrez-Torres, Daniela S.
Saunders, R. Jesse
Crandell, Jamie
Fry, Rebecca C.
Loomis, Dana
García-Vargas, Gonzalo G.
Del Razo, Luz M.
Stỳblo, Miroslav
Mendez, Michelle A.

January 2016

Variants in AS3MT, the gene encoding arsenic (+3 oxidation state) methyltranserase, have been shown ...

Efficient Arsenic Metabolism — The AS3MT Haplotype Is Associated with DNA Methylation and Expression of Multiple Genes Around AS3MT

Karin S. Engström (102997)
Mohammad Bakhtiar Hossain (102999)
Martin Lauss (103001)
Sultan Ahmed (103003)
Rubhana Raqib (103005)
Marie Vahter (17728)
Karin Broberg (103007)

January 2013

<div>Arsenic is a very potent toxicant. One major susceptibility factor for arsenic-related toxic...

Genome-Wide Association Study Identifies Chromosome 10q24.32 Variants Associated with Arsenic Metabolism and Toxicity Phenotypes in Bangladesh

Pierce, Brandon L.
Kibriya, Muhammad G.
Tong, Lin
Jasmine, Farzana
Argos, Maria
Roy, Shantanu
Paul-Brutus, Rachelle
Rahaman, Ronald
Rakibuz-Zaman, Muhammad
Parvez, Faruque
Ahmed, Alauddin
Quasem, Iftekhar
Hore, Samar K.
Alam, Shafiul
Islam, Tariqul
Slavkovich, Vesna
Gamble, Mary V.
Yunus, Md
Rahman, Mahfuzar
Baron, John A.
Graziano, Joseph H.
Ahsan, Habibul

January 2012

Arsenic contamination of drinking water is a major public health issue in many countries, increasing...

DETERMINANTS OF INTERINDIVIDUAL VARIABILITY IN ARSENIC SECONDARY METHYLATION EFFICIENCY IN A POPULATION FROM NORTHWEST MEXICO

Gomez Rubio, Paulina
Gomez Rubio, Paulina

January 2011

Chronic environmental exposure to inorganic arsenic is widely associated with human disease. Low hum...

Association of Cardiometabolic Genes with Arsenic Metabolism Biomarkers in American Indian Communities: The Strong Heart Family Study (SHFS)

Balakrishnan, Poojitha
Vaidya, Dhananjay
Franceschini, Nora
Saroja Voruganti,
Gribble, Matthew O.
Haack, Karin
Laston, Sandra
Umans, Jason G.
Francesconi, Kevin A.
Goessler, Walter
North, Kari E.
Lee, Elisa
Yracheta, Joseph
Best, Lyle G.
Maccluer, Jean W.
Kent, Jack
Cole, Shelley A.
Navas-Acien, Ana

January 2017

BACKGROUND: Metabolism of inorganic arsenic (iAs) is subject to inter-individual variability, which ...

Efficient arsenic metabolism--the AS3MT haplotype is associated with DNA methylation and expression of multiple genes around AS3MT.

Karin S Engström
Mohammad Bakhtiar Hossain
Martin Lauss
Sultan Ahmed
Rubhana Raqib
Marie Vahter
Karin Broberg

Arsenic is a very potent toxicant. One major susceptibility factor for arsenic-related toxicity is t...

Locus-Specific Differential DNA Methylation and Urinary Arsenic: An Epigenome-Wide Association Study in Blood among Adults with Low-to-Moderate Arsenic Exposure

Bozack, Anne K
Domingo-Relloso, Arce
Haack, Karin
Gamble, Mary V
Tellez-Plaza, Maria
Umans, Jason G
Best, Lyle G
Yracheta, Joseph
Gribble, Matthew O
Cardenas, Andres
Francesconi, Kevin A
Goessler, Walter
Tang, Wan-Yee
Fallin, M Daniele
Cole, Shelley A
Navas-Acien, Ana

June 2020

Background: Chronic exposure to arsenic (As), a human toxicant and carcinogen, remains a global publ...

Genetic variation in Glutathione S-Transferase Omega-1, Arsenic Methyltransferase and Methylene-tetrahydrofolate Reductase, arsenic exposure and bladder cancer: a case–control study

Beebe-Dimmer, Jennifer L
Iyer, Priyanka T
Nriagu, Jerome O
Keele, Greg R
Mehta, Shilpin
Meliker, Jaymie R
Lange, Ethan M
Schwartz, Ann G
Zuhlke, Kimberly A
Schottenfeld, David
Cooney, Kathleen A

January 2012

Abstract Background Ingestion of groundwater with high concentrations of inorganic arsenic has been ...

Heritability and Preliminary Genome-Wide Linkage Analysis of Arsenic Metabolites in Urine

Abstract

Extracted data

Heritability and Preliminary Genome-Wide Linkage Analysis of Arsenic Metabolites in Urine

Abstract

Extracted data

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