Outcomes of Combined Cardiovascular Risk Factor Management Strategies in Type 2 Diabetes: The ACCORD Randomized Trial
- Margolis, Karen L.
- O’Connor, Patrick J.
- Morgan, Timothy M.
- Buse, John B.
- Cohen, Robert M.
- Cushman, William C.
- Cutler, Jeffrey A.
- Evans, Gregory W.
- Gerstein, Hertzel C.
- Grimm, Richard H.
- Lipkin, Edward W.
- Narayan, K.M.Venkat
- Riddle, Matthew C.
- Sood, Ajay
- Goff, David C.
DOIAbstract
OBJECTIVETo compare effects of combinations of standard and intensive treatment of glycemia and either blood pressure (BP) or lipids in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial.RESEARCH DESIGN AND METHODSACCORD enrolled 10,251 type 2 diabetes patients aged 40–79 years at high risk for cardiovascular disease (CVD) events. Participants were randomly assigned to hemoglobin A1c goals of <6.0% (<42 mmol/mol; intensive glycemia) or 7.0–7.9% (53–63 mmol/mol; standard glycemia) and then randomized a second time to either 1) systolic BP goals of <120 mmHg (intensive BP) or <140 mmHg (standard BP) or 2) simvastatin plus fenofibrate (intensive lipid) or simvastatin plus placebo (standard lipid). Proportional hazards models ...
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