Trends in Incidence of Type 1 Diabetes Among Non-Hispanic White Youth in the U.S., 2002–2009
- Lawrence, Jean M.
- Imperatore, Giuseppina
- Dabelea, Dana
- Mayer-Davis, Elizabeth J.
- Linder, Barbara
- Saydah, Sharon
- Klingensmith, Georgeanna J.
- Dolan, Lawrence
- Standiford, Debra A.
- Pihoker, Catherine
- Pettitt, David J.
- Talton, Jennifer W.
- Thomas, Joan
- Bell, Ronny A.
- D’Agostino, Ralph B.
DOIAbstract
The SEARCH for Diabetes in Youth Study prospectively identified youth aged <20 years with physician-diagnosed diabetes. Annual type 1 diabetes (T1D) incidence per 100,000 person-years (95% CI) overall, by age-group, and by sex were calculated for at-risk non-Hispanic white (NHW) youth from 2002 through 2009. Joinpoint and Poisson regression models were used to test for temporal trends. The age- and sex-adjusted incidence of T1D increased from 24.4/100,000 (95% CI 23.9–24.8) in 2002 to 27.4/100,000 (26.9–27.9) in 2009 (P for trend = 0.0008). The relative annual increase in T1D incidence was 2.72% (1.18–4.28) per year; 2.84% (1.12–4.58) per year for males and 2.57% (0.68–4.51) per year for females. After adjustment for sex, significant increa...
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