Functional Redundancy of SWI/SNF Catalytic Subunits in Maintaining Vascular Endothelial Cells in the Adult Heart
- Willis, Monte S.
- Homeister, Jonathon W.
- Rosson, Gary B.
- Annayev, Yunus
- Holley, Darcy
- Holly, Stephen P.
- Madden, Victoria J.
- Godfrey, Virginia
- Parise, Leslie V.
- Bultman, Scott J.
Publication date
January 2012
DOIAbstract
SWI/SNF chromatin-remodeling complexes utilize either BRG1 or BRM as a catalytic subunit to alter nucleosome position and regulate gene expression. BRG1 is required for vascular endothelial cell (VEC) development and embryonic survival, whereas BRM is dispensable
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