The Sec14-like phosphatidylinositol transfer protein Sfh3 associates with bulk LDs in vegetative cells but targets to a neutral lipid hydrolase-rich LD pool during sporulation. Sfh3 inhibits LD utilization by a PtdIns-4-phosphate–dependent mechanism, and this inhibition prevents prospore membrane biogenesis in sporulating cells.Lipid droplet (LD) utilization is an important cellular activity that regulates energy balance and release of lipid second messengers. Because fatty acids exhibit both beneficial and toxic properties, their release from LDs must be controlled. Here we demonstrate that yeast Sfh3, an unusual Sec14-like phosphatidylinositol transfer protein, is an LD-associated protein that inhibits lipid mobilization from these partic...
Phospholipids provide an amphipathic barrier between lipid droplets and the cytoplasm of cells. In t...
ABSTRACT Lipins are evolutionarily conserved phosphatidate phosphatases that perform key functions i...
Cells prepare for fluctuations in nutrient availability by storing energy in the form of neutral lip...
The Sec14-like phosphatidylinositol transfer protein Sfh3 associates with bulk LDs in vegetative cel...
Lipid droplet (LD) utilization is an important cellular activity that regulates energy balance and r...
Lipid droplets (LDs) are important cellular organelles that govern the storage and turnover of lipid...
Intracellular lipid droplets (LDs) are remarkably dynamic and complex organelles that enact regulate...
AbstractSec14 family homologs are the major yeast phosphatidylinositol/phosphatidylcholine transfer ...
In virtually every cell, neutral lipids are stored in cytoplasmic structures called lipid droplets (...
Intracellular lipid droplets (LDs) are remarkably dynamic and complex organelles that enact regulate...
Metabolic energy is most efficiently stored as triacylglycerol (TAG). This neutral lipid accumulates...
Lipid droplets (LDs) are ubiquitous organelles that fulfill essential roles in response to metabolic...
Lipid droplets (LDs) are important cellular organelles that govern the storage and turnover of lipid...
Lipid droplets (LDs) are ubiquitous dynamic organelles that store and supply lipids in all eukaryoti...
International audienceEditorial Special issue "Biogenesis and Fate of Lipid Droplets" Intracellular ...
Phospholipids provide an amphipathic barrier between lipid droplets and the cytoplasm of cells. In t...
ABSTRACT Lipins are evolutionarily conserved phosphatidate phosphatases that perform key functions i...
Cells prepare for fluctuations in nutrient availability by storing energy in the form of neutral lip...
The Sec14-like phosphatidylinositol transfer protein Sfh3 associates with bulk LDs in vegetative cel...
Lipid droplet (LD) utilization is an important cellular activity that regulates energy balance and r...
Lipid droplets (LDs) are important cellular organelles that govern the storage and turnover of lipid...
Intracellular lipid droplets (LDs) are remarkably dynamic and complex organelles that enact regulate...
AbstractSec14 family homologs are the major yeast phosphatidylinositol/phosphatidylcholine transfer ...
In virtually every cell, neutral lipids are stored in cytoplasmic structures called lipid droplets (...
Intracellular lipid droplets (LDs) are remarkably dynamic and complex organelles that enact regulate...
Metabolic energy is most efficiently stored as triacylglycerol (TAG). This neutral lipid accumulates...
Lipid droplets (LDs) are ubiquitous organelles that fulfill essential roles in response to metabolic...
Lipid droplets (LDs) are important cellular organelles that govern the storage and turnover of lipid...
Lipid droplets (LDs) are ubiquitous dynamic organelles that store and supply lipids in all eukaryoti...
International audienceEditorial Special issue "Biogenesis and Fate of Lipid Droplets" Intracellular ...
Phospholipids provide an amphipathic barrier between lipid droplets and the cytoplasm of cells. In t...
ABSTRACT Lipins are evolutionarily conserved phosphatidate phosphatases that perform key functions i...
Cells prepare for fluctuations in nutrient availability by storing energy in the form of neutral lip...