Helicobacter pylori infection promotes male-predominant gastric adenocarcinoma in humans. Estrogens reduce gastric cancer risk and previous studies demonstrated that prophylactic 17β-estradiol (E2) in INS-GAS mice decreases H. pylori-induced carcinogenesis. We examined the effect of E2 and Tamoxifen, on H. pylori-induced gastric cancer in male and female INS-GAS mice. After confirming robust gastric pathology at 16 weeks post-infection (WPI), mice were implanted with E2, Tamoxifen, both E2 and Tamoxifen, or placebo pellets for 12 weeks. At 28 WPI, gastric histopathology, gene expression and immune cell infiltration were evaluated, and serum inflammatory cytokines measured. After treatment, no gastric cancer was observed in H. pylori-infecte...
Gastric cancer is a multifactorial neoplastic pathology numbering among its causes both environmenta...
Background: Gastric cancer is a serious health issue caused by H. pylori and claims more lives in de...
Gastric cancers are a significant cause of morbidity worldwide. Epidemiological studies and animal m...
Helicobacter pylori infection promotes male-predominant gastric adenocarcinoma in humans. Estrogens ...
Helicobacter pylori infection promotes male predominant gastric adenocarcinoma in humans. Estrogens ...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biological Engineering, 2011.This e...
Author Manuscript: 2010 October 15Helicobacter pylori infection causes severe dysplasia manifested a...
Gastric cancer is the second most common cause of cancer death worldwide, and annually it causes ove...
AbstractA specific increase in the level of a single coactivator appears to enhance estrogen action ...
Estrogens may influence gastric cancer risk but published studies are inconclusive. We therefore per...
Estrogensmay influence gastric cancer risk, but published studies are inconclusive.We therefore carr...
Infection with Helicobacter pylori, a Gram-negative, microaerophilic pathogen often results in gastr...
Objectives: Gastric colonisation with intestinal flora (IF) has been shown to promote Helicobacter p...
To maintain cellular homeostasis, the epithelial lining of the stomach wall continuously fluctuates ...
Epidemiological studies suggest pre-menopausal women have a reduced risk for sporadic and inflammati...
Gastric cancer is a multifactorial neoplastic pathology numbering among its causes both environmenta...
Background: Gastric cancer is a serious health issue caused by H. pylori and claims more lives in de...
Gastric cancers are a significant cause of morbidity worldwide. Epidemiological studies and animal m...
Helicobacter pylori infection promotes male-predominant gastric adenocarcinoma in humans. Estrogens ...
Helicobacter pylori infection promotes male predominant gastric adenocarcinoma in humans. Estrogens ...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biological Engineering, 2011.This e...
Author Manuscript: 2010 October 15Helicobacter pylori infection causes severe dysplasia manifested a...
Gastric cancer is the second most common cause of cancer death worldwide, and annually it causes ove...
AbstractA specific increase in the level of a single coactivator appears to enhance estrogen action ...
Estrogens may influence gastric cancer risk but published studies are inconclusive. We therefore per...
Estrogensmay influence gastric cancer risk, but published studies are inconclusive.We therefore carr...
Infection with Helicobacter pylori, a Gram-negative, microaerophilic pathogen often results in gastr...
Objectives: Gastric colonisation with intestinal flora (IF) has been shown to promote Helicobacter p...
To maintain cellular homeostasis, the epithelial lining of the stomach wall continuously fluctuates ...
Epidemiological studies suggest pre-menopausal women have a reduced risk for sporadic and inflammati...
Gastric cancer is a multifactorial neoplastic pathology numbering among its causes both environmenta...
Background: Gastric cancer is a serious health issue caused by H. pylori and claims more lives in de...
Gastric cancers are a significant cause of morbidity worldwide. Epidemiological studies and animal m...