A Newly Identified Susceptibility Locus near FOXP1 Modifies the Association of Gastroesophageal Reflux with Barrett's Esophagus
- Dai, James Y.
- De Dieu Tapsoba, Jean
- Buas, Matthew F.
- Onstad, Lynn E.
- Levine, David M.
- Risch, Harvey A.
- Chow, Wong Ho
- Bernstein, Leslie
- Ye, Weimin
- Lagergren, Jesper
- Bird, Nigel C.
- Corley, Douglas A.
- Shaheen, Nicholas J.
- Wu, Anna H.
- Reid, Brian J.
- Hardie, Laura J.
- Whiteman, David C.
- Vaughan, Thomas L.
Publication date
January 2015
DOIAbstract
Important risk factors for esophageal adenocarcinoma (EA) and its precursor, Barrett’s esophagus (BE) include gastroesophageal reflux disease, obesity, and cigarette-smoking. Recently, genome-wide association studies have identified seven germline single nucleotide polymorphisms (SNPs) that are associated with risk of BE and EA. Whether these genetic susceptibility loci modify previously identified exposure-disease associations is unclear
Add to ORKG