Genetic Predictors of Circulating 25-Hydroxyvitamin D and Risk of Colorectal Cancer
- Hiraki, Linda T.
- Qu, Conghui
- Hutter, Carolyn M.
- Baron, John A.
- Berndt, Sonja I.
- Bézieau, Stéphane
- Brenner, Hermann
- Caan, Bette J.
- Casey, Graham
- Chang-Claude, Jenny
- Chanock, Stephen J.
- Conti, David V.
- Duggan, David
- Fuchs, Charles S.
- Gallinger, Steven
- Giovannucci, Edward L.
- Harrison, Tabitha A.
- Hayes, Richard B.
- Hazra, Aditi
- Henderson, Brian
- Hoffmeister, Michael
- Hopper, John L.
- Hudson, Thomas J.
- Jenkins, Mark A.
- Küry, Sebastien
- Marchand, Loic Le
- Lemire, Mathieu
- Ma, Jing
- Manson, Jo Ann E.
- Nan, Hongmei
- Newcomb, Polly A.
- Ng, Kimmie
- Potter, John D.
- Schoen, Robert E.
- Schumacher, Fredrick R.
- Seminara, Daniela
- Slattery, Martha L.
- Wactawski-Wende, Jean
- White, Emily
- Wu, Kana
- Zanke, Brent W.
- Kraft, Peter
- Peters, Ulrike
- Chan, Andrew T.
Publication date
January 2013
DOIAbstract
Experimental evidence has demonstrated an anti-neoplastic role for vitamin D in the colon and higher circulating 25-hydroxyvitamin D (25[OH]D) levels are consistently associated with a lower risk of colorectal cancer (CRC). Genome-wide association studies have identified loci associated with levels of circulating 25(OH)D. The identified SNPs from four gene regions, collectively explain approximately 5% of the variance in circulating 25(OH)D
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