Single nucleotide polymorphisms in nucleotide excision repair genes, cancer treatment, and head and neck cancer survival
- Wyss, Annah B.
- Weissler, Mark C.
- Avery, Christy L.
- Herring, Amy H.
- Bensen, Jeannette T.
- Barnholtz-Sloan, Jill S.
- Funkhouser, William K.
- Olshan, Andrew F.
Publication date
January 2014
DOIAbstract
Head and neck cancers (HNC) are commonly treated with radiation and platinum-based chemotherapy, which produce bulky DNA adducts to eradicate cancerous cells. Because nucleotide excision repair (NER) enzymes remove adducts, variants in NER genes may be associated with survival among HNC cases both independently and jointly with treatment
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