Obstetric history and birth characteristics and Wilms Tumor: A report from the Children’s Onocolgy Group

Previous epidemiologic studies have suggested that various pregnancy and birth characteristics may be associated with Wilms tumor, a childhood kidney tumor. We evaluated obstetric events and birth characteristics in relation to Wilms tumor using data from a large North American case-control study. Mothers of 521 children with Wilms tumor and 517 controls, frequency matched on child’s age and geographic region, provided information about their labor and delivery history and their children’s birth characteristics through detailed computer assisted telephone interviews. Most obstetric factors were not associated with Wilms tumor, but modest associations were observed for labor induction (OR:1.4, 95% Confidence Interval (CI): 1.1,1.8), prenatal vaginal infection (OR: 1.8, 95% CI:1.2,2.8), and upper respiratory infection (OR: 1.5, 95% CI: 1.0,2.4). Low (4500g) birth weight and preterm delivery (