SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans

The effect of a selective CXCR2 antagonist (AZD5069) on human blood neutrophil count and innate immune functions.

Jurcevic, S.
Humfrey, C.
Uddin, M.
Warrington, S.
Larsson, B.
Keen, C.
Jurcevic, S.
Humfrey, C.
Uddin, M.
Warrington, S.
Larsson, B.
Keen, C.

January 2015

Abstract AIMS: The aim of the present study was to investigate whether selective antagonism of the ...

Discovery of Novel CXCR2 Inhibitors Using Ligand-Based Pharmacophore Models

Helen Ha (1545223)
Bikash Debnath (1545220)
Srinivas Odde (1545217)
Tim Bensman (1545214)
Henry Ho (1545226)
Paul M. Beringer (1545211)
Nouri Neamati (275633)

August 2015

The chemokine receptor CXCR2 is expressed on various immune cells and is essential for neutrophil re...

Comparative airway inflammatory response of normal volunteers to ozone and lipopolysaccharide challenge

Hernandez, Michelle L.
Harris, Bradford
Lay, John C.
Bromberg, Philip A.
Diaz-Sanchez, David
Devlin, Robert B.
Kleeberger, Steven R.
Alexis, Neil E.
Peden, David B.

January 2010

Ozone and lipopolysaccharide (LPS) are environmental pollutants with adverse health effects noted in...

SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans

Lazaar, Aili L.
Sweeney, Lisa E.
Macdonald, Alexander J.
Alexis, Neil E.
Chen, Chao
Tal-Singer, Ruth

January 2011

To determine the safety and tolerability of a novel selective CXCR2 antagonist and assess its pharma...

Safety and early treatment effects of the CXCR2 antagonist SB-656933 in patients with cystic fibrosis

Moss, Richard B.
Mistry, Sunil J.
Konstan, Michael W.
Pilewski, Joseph M.
Kerem, Eitan
Tal-Singer, Ruth
Lazaar, Aili L.

May 2013

AbstractBackgroundIt is hypothesized that a CXCR2 receptor antagonist would inhibit the recruitment ...

Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: a randomized, placebo-controlled clinical trial

Nair, P.
Gaga, M.
Zervas, E.
Alagha, K.
Hargreave, F. E.
O'Byrne, P. M.
Stryszak, P.
Gann, L.
Sadeh, J.
Chanez, P.

July 2012

Background: Increased numbers of neutrophils are reported in the airways of patients with severe ast...

CXCL-8-dependent and -independent neutrophil activation in COPD:experiences from a pilot study of the CXCR2 antagonist danirixin

Keir, Holly R.
Richardson, Hollian
Fillmore, Christina
Shoemark, Amelia
Lazaar, Aili L.
Miller, Bruce E.
Tal-Singer, Ruth
Chalmers, James D.
Mohan, Divya

November 2020

The implications of these findings are significant for development of CXCR2 antagonists and other me...

Safety and efficacy of Pur118 in the ozone challenge model

Holz, Olaf
Biller, Heike
Müller, Meike
Kane, Katie
Rosano, Molly
Hanrahan, John
Hava, David L.
Hohlfeld, Jens Michael

January 2014

INTRODUCTION: The ozone challenge model can be used to assess the efficacy of novel anti-inflammator...

REFERENCES

September 2016

human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis. Sci Transl Med 2...

Validation of the Human Ozone Challenge Model as a Tool for Assessing Anti-Inflammatory Drugs in Early Development

Holz, Olaf
Tal-Singer, Ruth
Kanniess, Frank
Simpson, Kathy J.
Gibson, Anthony
Vessey, Rupert S. J.
Janicki, Stanislawa
Magnussen, Helgo
Jörres, Rudolf A.
Richter, Kai

January 2005

This study aimed to test the utility of the ozone challenge model for profiling novel compounds desi...

Effects of an anti-inflammatory VAP-1/SSAO inhibitor, PXS-4728A, on pulmonary neutrophil migration

Schilter, HC
Collison, A
Russo, RC
Foot, JS
Yow, TT
Vieira, AT
Tavares, LD
Mattes, J
Teixeira, MM
Jarolimek, W

March 2015

Airway inflammation evaluated in a human nasal lipopolysaccharide challenge model by investigating the effect of a CXCR2 inhibitor.

Virtala, R
Ekman, A-K
Jansson, L
Westin, Ulla
Cardell, Lars-Olaf

January 2012

BACKGROUND: The existence of a link between inflammation in upper and lower airways is well establis...

Identification of small-molecules targeting CXCR2 function and signaling

Ha, Helen Nen

July 2013

2013-07-30Chemokine receptor, CXCR2, and its ligands are an essential component of the immune system...

Nonpeptide CXCR2 antagonist prevents neutrophil accumulation in hyperoxia-exposed newborn rats

Richard L. Auten
Ricardo M. Richardson
John R. White
S. Nicholas Mason
Michael A. Vozzelli
Mary H. Whorton

January 2001

Neutrophil influx in lung injury is controlled in part by chemo-kines acting through the receptor, C...

Efficacy and safety of inhaled calcium lactate PUR118 in the ozone challenge model - a clinical trial

Holz, Olaf
Biller, Heike
Müller, Meike
Kane, Katie
Rosano, Molly
Hanrahan, John
Hava, David L.
Hohlfeld, Jens M.

January 2015

Background: The ozone challenge model can be used to assess the efficacy of anti-inflammatory compou...

The effect of a selective CXCR2 antagonist (AZD5069) on human blood neutrophil count and innate immune functions.

Jurcevic, S.
Humfrey, C.
Uddin, M.
Warrington, S.
Larsson, B.
Keen, C.
Jurcevic, S.
Humfrey, C.
Uddin, M.
Warrington, S.
Larsson, B.
Keen, C.

January 2015

Abstract AIMS: The aim of the present study was to investigate whether selective antagonism of the ...

Discovery of Novel CXCR2 Inhibitors Using Ligand-Based Pharmacophore Models

Helen Ha (1545223)
Bikash Debnath (1545220)
Srinivas Odde (1545217)
Tim Bensman (1545214)
Henry Ho (1545226)
Paul M. Beringer (1545211)
Nouri Neamati (275633)

August 2015

The chemokine receptor CXCR2 is expressed on various immune cells and is essential for neutrophil re...

Comparative airway inflammatory response of normal volunteers to ozone and lipopolysaccharide challenge

Hernandez, Michelle L.
Harris, Bradford
Lay, John C.
Bromberg, Philip A.
Diaz-Sanchez, David
Devlin, Robert B.
Kleeberger, Steven R.
Alexis, Neil E.
Peden, David B.

January 2010

Ozone and lipopolysaccharide (LPS) are environmental pollutants with adverse health effects noted in...

SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans

Lazaar, Aili L.
Sweeney, Lisa E.
Macdonald, Alexander J.
Alexis, Neil E.
Chen, Chao
Tal-Singer, Ruth

January 2011

To determine the safety and tolerability of a novel selective CXCR2 antagonist and assess its pharma...

Safety and early treatment effects of the CXCR2 antagonist SB-656933 in patients with cystic fibrosis

Moss, Richard B.
Mistry, Sunil J.
Konstan, Michael W.
Pilewski, Joseph M.
Kerem, Eitan
Tal-Singer, Ruth
Lazaar, Aili L.

May 2013

AbstractBackgroundIt is hypothesized that a CXCR2 receptor antagonist would inhibit the recruitment ...

Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: a randomized, placebo-controlled clinical trial

Nair, P.
Gaga, M.
Zervas, E.
Alagha, K.
Hargreave, F. E.
O'Byrne, P. M.
Stryszak, P.
Gann, L.
Sadeh, J.
Chanez, P.

July 2012

Background: Increased numbers of neutrophils are reported in the airways of patients with severe ast...

CXCL-8-dependent and -independent neutrophil activation in COPD:experiences from a pilot study of the CXCR2 antagonist danirixin

Keir, Holly R.
Richardson, Hollian
Fillmore, Christina
Shoemark, Amelia
Lazaar, Aili L.
Miller, Bruce E.
Tal-Singer, Ruth
Chalmers, James D.
Mohan, Divya

November 2020

The implications of these findings are significant for development of CXCR2 antagonists and other me...

Safety and efficacy of Pur118 in the ozone challenge model

Holz, Olaf
Biller, Heike
Müller, Meike
Kane, Katie
Rosano, Molly
Hanrahan, John
Hava, David L.
Hohlfeld, Jens Michael

January 2014

INTRODUCTION: The ozone challenge model can be used to assess the efficacy of novel anti-inflammator...

REFERENCES

September 2016

human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis. Sci Transl Med 2...

Validation of the Human Ozone Challenge Model as a Tool for Assessing Anti-Inflammatory Drugs in Early Development

Holz, Olaf
Tal-Singer, Ruth
Kanniess, Frank
Simpson, Kathy J.
Gibson, Anthony
Vessey, Rupert S. J.
Janicki, Stanislawa
Magnussen, Helgo
Jörres, Rudolf A.
Richter, Kai

January 2005

This study aimed to test the utility of the ozone challenge model for profiling novel compounds desi...

Effects of an anti-inflammatory VAP-1/SSAO inhibitor, PXS-4728A, on pulmonary neutrophil migration

Schilter, HC
Collison, A
Russo, RC
Foot, JS
Yow, TT
Vieira, AT
Tavares, LD
Mattes, J
Teixeira, MM
Jarolimek, W

March 2015

Airway inflammation evaluated in a human nasal lipopolysaccharide challenge model by investigating the effect of a CXCR2 inhibitor.

Virtala, R
Ekman, A-K
Jansson, L
Westin, Ulla
Cardell, Lars-Olaf

January 2012

BACKGROUND: The existence of a link between inflammation in upper and lower airways is well establis...

Identification of small-molecules targeting CXCR2 function and signaling

Ha, Helen Nen

July 2013

2013-07-30Chemokine receptor, CXCR2, and its ligands are an essential component of the immune system...

Nonpeptide CXCR2 antagonist prevents neutrophil accumulation in hyperoxia-exposed newborn rats

Richard L. Auten
Ricardo M. Richardson
John R. White
S. Nicholas Mason
Michael A. Vozzelli
Mary H. Whorton

January 2001

Neutrophil influx in lung injury is controlled in part by chemo-kines acting through the receptor, C...

Efficacy and safety of inhaled calcium lactate PUR118 in the ozone challenge model - a clinical trial

Holz, Olaf
Biller, Heike
Müller, Meike
Kane, Katie
Rosano, Molly
Hanrahan, John
Hava, David L.
Hohlfeld, Jens M.

January 2015

Background: The ozone challenge model can be used to assess the efficacy of anti-inflammatory compou...

The effect of a selective CXCR2 antagonist (AZD5069) on human blood neutrophil count and innate immune functions.

Jurcevic, S.
Humfrey, C.
Uddin, M.
Warrington, S.
Larsson, B.
Keen, C.
Jurcevic, S.
Humfrey, C.
Uddin, M.
Warrington, S.
Larsson, B.
Keen, C.

January 2015

Abstract AIMS: The aim of the present study was to investigate whether selective antagonism of the ...

Discovery of Novel CXCR2 Inhibitors Using Ligand-Based Pharmacophore Models

Helen Ha (1545223)
Bikash Debnath (1545220)
Srinivas Odde (1545217)
Tim Bensman (1545214)
Henry Ho (1545226)
Paul M. Beringer (1545211)
Nouri Neamati (275633)

August 2015

The chemokine receptor CXCR2 is expressed on various immune cells and is essential for neutrophil re...

Comparative airway inflammatory response of normal volunteers to ozone and lipopolysaccharide challenge

Hernandez, Michelle L.
Harris, Bradford
Lay, John C.
Bromberg, Philip A.
Diaz-Sanchez, David
Devlin, Robert B.
Kleeberger, Steven R.
Alexis, Neil E.
Peden, David B.

January 2010

Ozone and lipopolysaccharide (LPS) are environmental pollutants with adverse health effects noted in...

SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans

Abstract

Extracted data

SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans

Abstract

Extracted data

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