Common genetic variations in the LEP and LEPR genes, obesity and breast cancer incidence and survival
- Cleveland, Rebecca J.
- Gammon, Marilie D.
- Long, Chang Min
- Gaudet, Mia M.
- Eng, Sybil M.
- Teitelbaum, Susan L.
- Neugut, Alfred I.
- Santella, Regina M.
Publication date
January 2010
DOIAbstract
Obesity is a strong risk factor for breast cancer in postmenopausal women and adverse prognostic indicator regardless of menopausal status. Leptin is an important regulator of adipose tissue mass and has been associated with tumor cell growth. Leptin exerts its effects through interaction with the leptin receptor (LEPR). We investigated whether genetic variations in the leptin (LEP) and LEPR genes are associated with risk of breast cancer, or once diagnosed, with survival
Add to ORKG