Effectiveness of etoposide chemomobilization in lymphoma patients undergoing auto-SCT
- Wood, W. A.
- Whitley, J.
- Goyal, R.
- Brown, P. M.
- Sharf, A.
- Irons, R.
- Rao, K. V.
- Essenmacher, A.
- Serody, J. S.
- Coghill, J. M.
- Armistead, P. M.
- Sarantopoulos, S.
- Gabriel, D. A.
- Shea, T. C.
DOIAbstract
The effectiveness of stem cell mobilization with G-CSF in lymphoma patients is suboptimal. We reviewed our institutional experience using chemomobilization with etoposide (VP-16; 375 mg/m2 on days +1 and +2) and G-CSF (5 μg/kg twice daily from day +3 through the final day of collection) in 159 patients with lymphoma. This approach resulted in successful mobilization (>2 × 106 CD34+ cells collected) in 94% of patients (83% within 4 apheresis sessions). Fifty-seven percent of patients yielded at least 5 × 106 cells in 2 days and were defined as good mobilizers. The regimen was safe with a low rate of rehospitalization. Average costs were $14 923 for good mobilizers and $27 044 for poor mobilizers (P<0.05). Using our data, we performed a ‘brea...
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