Cytotoxic calanquinone A from Calanthe arisanensis and its first total synthesis
- Lee, Chia Lin
- Nakagawa-Goto, Kyoko
- Yu, Donglei
- Liu, Yi Nan
- Bastow, Kenneth F.
- Morris-Natschke, Susan L.
- Chang, Fang Rong
- Wu, Yang Chang
- Lee, Kuo Hsiung
Publication date
January 2008
DOIAbstract
Calanquinone A (1) was isolated from an EtOAc-soluble extract of Calanthe arisanensis through bioassay-guided fractionation. Its structure was identified by spectroscopic methods. Compound 1 showed potent cytotoxicity (EC50 < 0.5 µg/mL) against lung (A549), prostate (PC-3 and DU145), colon (HCT-8), breast (MCF7), nasopharyngeal (KB), and vincristine-resistant nasopharyngeal (KB-VIN) cancer cell lines, and interestingly, showed an improved drug resistance profile compared to paclitaxel. The total synthesis of 1 was also achieved and reported herein
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