Thymidylate synthase (TSase) is a 62 kDa homodimeric enzyme required for de novo synthesis of thymidine monophosphate (dTMP) in most organisms. This makes the enzyme an excellent target for anticancer and microbial antibiotic drugs. In addition, TSase has been shown to exhibit negative cooperativity and half-the-sites reactivity. For these collective reasons, TSase is widely studied, and much is known about its kinetics and structure as it progresses through a multi-step catalytic cycle. Recently, nuclear magnetic resonance (NMR) spin relaxation has been instrumental in demonstrating the critical role of dynamics in enzyme function in small model systems. These studies raise questions about how dynamics affect function in larger enzymes wit...
Enzymes are highly dynamic molecules that undergo motions on a wide variety of timescales that are l...
The cleavage of covalent C–H bonds is one of the most energetically demanding, yet biologically esse...
Thymidylate synthase (TSase) produces the sole intracellular de novo source of thymidine (i.e. the D...
Thymidylate synthase (TSase) is a 62 kDa homodimeric enzyme required for de novo synthesis of thymid...
Thymidylate synthase (TSase) is a clinically important enzyme because it catalyzes synthesis of the ...
Human thymidylate synthase (hTS) is essential for DNA replication and therefore a therapeutic target...
Thymidylate synthase (TSase) is responsible for synthesizing the sole de novo source of dTMP in all ...
Thymidylate Synthase (TSase) is a highly conserved enzyme that catalyzes the production of the DNA b...
<div><p>Thymidylate Synthase (TSase) is a highly conserved enzyme that catalyzes the production of t...
Thymidylate synthase (TSase) is responsible for synthesizing the sole <i>de novo</i> source of dTMP ...
The enzyme thymidylate synthase (TS) is an important drug target. However, after long-term exposure ...
Thymidylate synthase (TS) catalyzes the conversion of dUMP into dTMP via a methyl transfer from the ...
In cells, thymidylate synthases provide the only de novo source of 2′-deoxythymidine-5′-...
The catalytic mechanism of thymidylate synthase (TS) was investigated using X-ray crystallography: f...
The urgent need for new antibiotics poses a challenge to target un(der)exploited vital cellular proc...
Enzymes are highly dynamic molecules that undergo motions on a wide variety of timescales that are l...
The cleavage of covalent C–H bonds is one of the most energetically demanding, yet biologically esse...
Thymidylate synthase (TSase) produces the sole intracellular de novo source of thymidine (i.e. the D...
Thymidylate synthase (TSase) is a 62 kDa homodimeric enzyme required for de novo synthesis of thymid...
Thymidylate synthase (TSase) is a clinically important enzyme because it catalyzes synthesis of the ...
Human thymidylate synthase (hTS) is essential for DNA replication and therefore a therapeutic target...
Thymidylate synthase (TSase) is responsible for synthesizing the sole de novo source of dTMP in all ...
Thymidylate Synthase (TSase) is a highly conserved enzyme that catalyzes the production of the DNA b...
<div><p>Thymidylate Synthase (TSase) is a highly conserved enzyme that catalyzes the production of t...
Thymidylate synthase (TSase) is responsible for synthesizing the sole <i>de novo</i> source of dTMP ...
The enzyme thymidylate synthase (TS) is an important drug target. However, after long-term exposure ...
Thymidylate synthase (TS) catalyzes the conversion of dUMP into dTMP via a methyl transfer from the ...
In cells, thymidylate synthases provide the only de novo source of 2′-deoxythymidine-5′-...
The catalytic mechanism of thymidylate synthase (TS) was investigated using X-ray crystallography: f...
The urgent need for new antibiotics poses a challenge to target un(der)exploited vital cellular proc...
Enzymes are highly dynamic molecules that undergo motions on a wide variety of timescales that are l...
The cleavage of covalent C–H bonds is one of the most energetically demanding, yet biologically esse...
Thymidylate synthase (TSase) produces the sole intracellular de novo source of thymidine (i.e. the D...