Ethnic Stratification of the Association of RGS4 Variants with Antipsychotic Treatment Response in Schizophrenia
- Campbell, Daniel B.
- Ebert, Philip J.
- Skelly, Tara
- Stroup, T. Scott
- Lieberman, Jeffrey
- Levitt, Pat
- Sullivan, Patrick F.
Publication date
January 2008
DOIAbstract
Genetic association studies, including a large meta-analysis, report association of Regulator of G Protein Signaling 4 (RGS4) with schizophrenia in the context of heterogeneity. The central role of RGS4 in regulating signaling via Gi/o coupled neurotransmitter receptors led us to hypothesize that there may be RGS4 genotypes predictive of specific disease phenotypes and antipsychotic treatment responses
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