Large candidate gene association study reveals genetic risk factors and therapeutic targets for fibromyalgia
- Smith, Shad B.
- Maixner, Dylan W.
- Fillingim, Roger B.
- Slade, Gary
- Gracely, Richard H.
- Ambrose, Kirsten
- Zaykin, Dmitri V.
- Hyde, Craig
- John, Sally
- Tan, Keith
- Maixner, William
- Diatchenko, Luda
Publication date
January 2012
DOIAbstract
Fibromyalgia (FM) represents a complex disorder characterized by widespread pain and tenderness and frequently accompanied by additional somatic and cognitive/affective symptoms. Genetic risk factors are known to contribute to the etiology of the syndrome, but few specific genetic variants have been identified to date and still require replication. In this study, a large scale candidate gene approach was used to examine over 350 genes for association with FM
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