A functional RANKL polymorphism associated with younger age at onset of rheumatoid arthritis
- Tan, Wenfeng
- Wu, Hui
- Zhao, Jian
- Derber, Lezlie A.
- Lee, David M.
- Shadick, Nancy A.
- Conn, Doyt L.
- Smith, Edwin A.
- Gersuk, Vivian H.
- Nepom, Gerald T.
- Moreland, Larry W.
- Furst, Daniel E.
- Thompson, Susan D.
- Jonas, Beth L.
- Holers, V. Michael
- Glass, David N.
- Chen, Pojen P.
- Bridges, S. Louis
- Weinblatt, Michael E.
- Paulus, Harold E.
- Tsao, Betty P.
Publication date
January 2010
DOIAbstract
We previously reported association of co-occurrence of HLA-DRB1 shared epitope (SE) and RANKL SNPs with younger age of RA onset in 182 rheumatoid factor positive (RF) European American (EA) early RA patients. Here, we fine-mapped the 48 kb RANKL region in the extended 210 EA RF-positive early RA cohort, sought replication of RA-associated SNPs in additional 501 EA and 298 African-Americans (AA) RA cohorts, and explored functional consequences of RA-associated SNPs
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