Lysine Acetyltransferase PCAF Is a Key Regulator of Arteriogenesis
- Bastiaansen, A. J. N. M.
- Ewing, M. M.
- de Boer, H. C.
- van der Pouw Kraan, T. C.
- de Vries, M. R.
- Peters, E. A. B.
- Welten, S. M. J.
- Arens, R.
- Moore, S. M.
- Faber, J. E.
- Jukema, J. W.
- Hamming, J. F.
- Nossent, A. Y.
- Quax, P. H. A.
Publication date
January 2013
DOIAbstract
Therapeutic arteriogenesis, i.e., expansive remodeling of pre-existing collaterals, using single-action factor therapies has not been as successful as anticipated. Modulation of factors that act as a master switch for relevant gene programs may prove more effective. Transcriptional co-activator P300/CBP-associated factor (PCAF) has histone acetylating activity and promotes transcription of multiple inflammatory genes. Because arteriogenesis is an inflammation-driven process, we hypothesized that PCAF acts as multifactorial regulator of arteriogenesis
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