Surra is an animal pathogenic protozoan infection, caused by Trypanosoma evansi, that develops into a fatal wasting disease. Control measures rely on diagnosis and treatment. However, with the continuous emergence of drug resistance, this tactic is failing, and the pressing need for new chemotherapeutic agents is becoming critical. With the introduction of novel aromatic diamidines, a new category of antitrypanosomal drugs was discovered. Nevertheless, their efficacy within a T. evansi-infected mouse model was not known. In total, 30 compounds previously selected based on their in vitro activity were tested in a T. evansi mouse model of infection. Six of the compounds were capable of curing T. evansi-infected mice at drug doses as low as 0....
The current treatment of Chagas disease (CD), based on nifurtimox and benznidazole (Bz), is unsatisf...
Animal African trypanosomiasis (AAT) is a significant socioeconomic burden for sub-Saharan Africa be...
The human and veterinary disease complex known as African trypanosomiasis continues to inflict signi...
Surra is an animal pathogenic protozoan infection, caused by Trypanosoma evansi, that develops into ...
Three diamidines (DB 75, DB 867 and DB 1192) were selected and their ability to cure T. evansi exper...
ABSTRACT African animal trypanosomosis (AAT) is caused by the tsetse fly-transmitted protozoans Tryp...
Trypanosoma equiperdum is a protozoan parasite responsible for causing Dourine, a debilitating negle...
African animal trypanosomosis (AAT) is caused by the tsetse fly-transmitted protozoans Trypanosoma c...
The aromatic diamidine pentamidine has long been used to treat early-stage human African trypanosomi...
ABSTRACT Dicationic diamidines, such as diminazene and pentamidine, are well-studied chemotherapeuti...
This is the published version.Human African trypanosomiasis (HAT), a neglected tropical disease, is ...
This is the published version.African sleeping sickness is a neglected tropical disease transmitted ...
The current treatment of Chagas disease (CD), based on nifurtimox and benznidazole (Bz), is unsatisf...
Animal African trypanosomiasis (AAT) is a significant socioeconomic burden for sub-Saharan Africa be...
The human and veterinary disease complex known as African trypanosomiasis continues to inflict signi...
Surra is an animal pathogenic protozoan infection, caused by Trypanosoma evansi, that develops into ...
Three diamidines (DB 75, DB 867 and DB 1192) were selected and their ability to cure T. evansi exper...
ABSTRACT African animal trypanosomosis (AAT) is caused by the tsetse fly-transmitted protozoans Tryp...
Trypanosoma equiperdum is a protozoan parasite responsible for causing Dourine, a debilitating negle...
African animal trypanosomosis (AAT) is caused by the tsetse fly-transmitted protozoans Trypanosoma c...
The aromatic diamidine pentamidine has long been used to treat early-stage human African trypanosomi...
ABSTRACT Dicationic diamidines, such as diminazene and pentamidine, are well-studied chemotherapeuti...
This is the published version.Human African trypanosomiasis (HAT), a neglected tropical disease, is ...
This is the published version.African sleeping sickness is a neglected tropical disease transmitted ...
The current treatment of Chagas disease (CD), based on nifurtimox and benznidazole (Bz), is unsatisf...
Animal African trypanosomiasis (AAT) is a significant socioeconomic burden for sub-Saharan Africa be...
The human and veterinary disease complex known as African trypanosomiasis continues to inflict signi...